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Aqp1tm1Ask
Targeted Allele Detail
Summary
Symbol: Aqp1tm1Ask
Name: aquaporin 1; targeted mutation 1, Alan S Verkman
MGI ID: MGI:1857807
Synonyms: AQP1-
Gene: Aqp1  Location: Chr6:55313417-55325540 bp, + strand  Genetic Position: Chr6, 27.38 cM
Alliance: Aqp1tm1Ask page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45888
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A 1.8 kb neomycin cassette replaced part of the exon 1 coding sequence and ~1.3 kb of intron 1. Northern blot analysis of kidney, lung, eye, spleen, and heart homogenates from homozygous mutant mice did not detect full-length transcripts. Western blots of kidney, lung, eye, spleen, and heart homogenates from homozygous mutant mice did not detect showed no detectable encoded protein. (J:45888)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 224 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aqp1 Mutation:  23 strains or lines available
References
Original:  J:45888 Ma T, et al., Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels. J Biol Chem. 1998 Feb 20;273(8):4296-9
All:  85 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory