Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Acox1tm1Jkr Name: acyl-Coenzyme A oxidase 1, palmitoyl; targeted mutation 1, Janardan K Reddy MGI ID: MGI:1857811 Synonyms: ACOX-, Acox1-, AOX- Gene: Acox1  Location: Chr11:116062714-116089605 bp, - strand  Genetic Position: Chr11, 80.96 cM Alliance: Acox1tm1Jkr page

Hepatocellular alterations in liver of Acox1tm1Jkr/Acox1tm1Jkr mice Show the 7 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:35794
Parent Cell Line:	BK4 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.3kb SstI-BamHI segment containing exons 8 and 9 was replaced with a neomycin selection cassette. The 3.8-kb transcript is undetectable in RNA derived from the livers of homozygous mice by Northern blot. Western blots and enzymatic assays confirmed the absence of functional protein in homozygous mice. (J:35794)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

List all tumor models in MMHCdb carrying Acox1tm1Jkr

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acox1 Mutation:	42 strains or lines available

Original:	J:35794 Fan CY, et al., Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene. J Biol Chem. 1996 Oct 4;271(40):24698-710
All:	19 reference(s)