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Hoxb1tm1Mrc
Targeted Allele Detail
Summary
Symbol: Hoxb1tm1Mrc
Name: homeobox B1; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:1857824
Synonyms: hoxb-1neo
Gene: Hoxb1  Location: Chr11:96256578-96259082 bp, + strand  Genetic Position: Chr11, 59.86 cM
Alliance: Hoxb1tm1Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36235
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Replacement of a 371 bp BglII fragment of exon 2 with a neomycin cassette. A very low level of HOXB1 immunoreactivity was detectable in homozygous embryos by whole-mount immunohistochemistry. (J:36235)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb1 Mutation:  24 strains or lines available
References
Original:  J:36235 Goddard JM, et al., Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development. 1996 Oct;122(10):3217-28
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory