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Dlx1tm1Jlr
Targeted Allele Detail
Summary
Symbol: Dlx1tm1Jlr
Name: distal-less homeobox 1; targeted mutation 1, John L Rubenstein
MGI ID: MGI:1857826
Synonyms: Dlx-1-, Dlx-1-D2.8/neo
Gene: Dlx1  Location: Chr2:71358457-71364325 bp, + strand  Genetic Position: Chr2, 42.61 cM
Alliance: Dlx1tm1Jlr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40427
Parent Cell Line:  JM-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A PGK-neomycin resistance cassette replaced exons 2 and 3 of the Dlx1 gene. (J:40427)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 60 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dlx1 Mutation:  21 strains or lines available
References
Original:  J:40427 Qiu M, et al., Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches. Dev Biol. 1997 May 15;185(2):165-84
All:  25 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
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