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Pitx2tm1Sac
Targeted Allele Detail
Summary
Symbol: Pitx2tm1Sac
Name: paired-like homeodomain transcription factor 2; targeted mutation 1, Sally A Camper
MGI ID: MGI:1857844
Synonyms: Pitx2-, Pitx2neo
Gene: Pitx2  Location: Chr3:128993527-129013240 bp, + strand  Genetic Position: Chr3, 57.84 cM
Alliance: Pitx2tm1Sac page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51160
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, Hypomorph)
Mutation:    Insertion
 
Mutation details: Gene targeting was performed with a vector engineered to contain a loxP site downstream from exon 4 and a floxed neomycin cassette upstream of exon 4. This allele is a demonstrated hypomorph. (J:51160)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pitx2 Mutation:  39 strains or lines available
References
Original:  J:51160 Gage PJ, et al., Dosage requirement of Pitx2 for development of multiple organs. Development. 1999 Oct;126(20):4643-51
All:  14 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory