Hnf1b<tm1Sce> Targeted Allele Detail MGI Mouse (MGI:1857856)

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Hnf1b^tm1Sce
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Hnf1b^tm1Sce
Name:	HNF1 homeobox B; targeted mutation 1, Silvia Cereghini
MGI ID:	MGI:1857856
Synonyms:	Hnf1b^lacZ, vHnf1^-, vHNF1^{deltaExon1-SC}
Gene:	Hnf1b Location: Chr11:83741035-83796743 bp, + strand Genetic Position: Chr11, 51.23 cM
Alliance:	Hnf1b^tm1Sce page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:58079
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1^b-m3

Mutation
description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exon 1 was replaced by a construct containing lacZ and neo. The deleted coding sequence encodes the entire N-terminal dimerization domain and a portion of another domain showing homology to either the human POU-A subdomain or human B-domain. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. Beta-galactosidase was expressed under the control of the endogenous promoter. (J:58079)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	49 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Hnf1b Mutation:	16 strains or lines available

References

Original:	J:58079 Barbacci E, et al., Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification. Development. 1999 Nov;126(21):4795-805
All:	10 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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