Parp1<tm1Zqw> Targeted Allele Detail MGI Mouse (MGI:1857862)

Parp1^tm1Zqw
Targeted Allele Detail

Summary

Symbol:	Parp1^tm1Zqw
Name:	poly (ADP-ribose) polymerase family, member 1; targeted mutation 1, Zhao-Qi Wang
MGI ID:	MGI:1857862
Synonyms:	ADPRT^-, Adprt1^tm1Wag, ARTD1^-, PARP-, PARP-1-, PARS^-, PKO
Gene:	Parp1 Location: Chr1:180396456-180428564 bp, + strand Genetic Position: Chr1, 84.44 cM, cytoband H5
Alliance:	Parp1^tm1Zqw page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:23942
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A promoterless neomycin gene replaced part of exon 2 and intron 2. The neomycin sequences were fused in-frame to the coding sequence of the gene. Northern blot analysis detected a truncated fusion transcript in homozygous mice. Enzyme activity assays demonstrated a lack of functional ADPRT1 protein in homozygous mice. (J:23942)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	14 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Parp1^tm1Zqw

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available Cell Lines: 0 lines available
Carrying any Parp1 Mutation:	66 strains or lines available

References

Original:	J:23942 Wang ZQ, et al., Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev. 1995 Mar 1;9(5):509-20
All:	126 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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