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Hoxd13tm1Ddu
Targeted Allele Detail
Summary
Symbol: Hoxd13tm1Ddu
Name: homeobox D13; targeted mutation 1, Denis Duboule
MGI ID: MGI:1857871
Synonyms: Hoxd-13-, Hoxd-13St
Gene: Hoxd13  Location: Chr2:74498654-74501943 bp, + strand  Genetic Position: Chr2, 44.13 cM
Alliance: Hoxd13tm1Ddu page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:15507
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A neomycin cassette was inserted into the sequences encoding the 11th amino acid of the homeobox domain. (J:15507)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd13 Mutation:  24 strains or lines available
References
Original:  J:15507 Dolle P, et al., Disruption of the Hoxd-13 gene induces localized heterochrony leading to mice with neotenic limbs. Cell. 1993 Nov 5;75(3):431-41
All:  17 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory