Msr1<tm1Csk> Targeted Allele Detail MGI Mouse (MGI:1857874)

Msr1^tm1Csk
Targeted Allele Detail

Summary

Symbol:	Msr1^tm1Csk
Name:	macrophage scavenger receptor 1; targeted mutation 1, Chugai Pharmaceutical Co, Ltd
MGI ID:	MGI:1857874
Synonyms:	MSR-, Msr1-KO, Msr1^tm1Kod, Scara1^_, Scvr^tm1, SR-, Sra^-, SR-A-, SR-AI/II KO, SRAKO, SRKO
Gene:	Msr1 Location: Chr8:40034726-40095714 bp, - strand Genetic Position: Chr8, 23.89 cM
Alliance:	Msr1^tm1Csk page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:39079
Parent Cell Line:	A3-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin cassette was inserted into the EcoRI site in exon 4, which encodes the alpha helical coiled-coil structure essential for the formation of functional trimeric receptors. Protein was not detectable by immunostaining of liver sections from homozygous mutant animals. (J:39079)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 5 strains available Cell Lines: 0 lines available
Carrying any Msr1 Mutation:	12 strains or lines available

References

Original:	J:39079 Suzuki H, et al., A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature. 1997 Mar 20;386(6622):292-6
All:	139 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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