Drd2<tm1Low> Targeted Allele Detail MGI Mouse (MGI:1857875)

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Drd2^tm1Low
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Drd2^tm1Low
Name:	dopamine receptor D2; targeted mutation 1, Malcolm J Low
MGI ID:	MGI:1857875
Synonyms:	D2-, D2 KO, D2KO, D2R^-, Drd2-
Gene:	Drd2 Location: Chr9:49251927-49319477 bp, + strand Genetic Position: Chr9, 26.72 cM
Alliance:	Drd2^tm1Low page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:41858
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A genomic fragment containing exon 7 and part of exon 8 was replaced by a neomycin resistance cassette. (J:41858)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Drd2 Mutation:	70 strains or lines available

References

Original:	J:41858 Kelly MA, et al., Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron. 1997 Jul;19(1):103-13
All:	104 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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