Pgr<tm1Bwo> Targeted Allele Detail MGI Mouse (MGI:1857933)

Pgr^tm1Bwo
Targeted Allele Detail

Summary

Symbol:	Pgr^tm1Bwo
Name:	progesterone receptor; targeted mutation 1, Bert W O'Malley
MGI ID:	MGI:1857933
Synonyms:	PR^-, PRKO
Gene:	Pgr Location: Chr9:8899834-8968612 bp, + strand Genetic Position: Chr9, 2.46 cM
Alliance:	Pgr^tm1Bwo page

Uterine defects in Pgr^tm4.2Lyd/Pgr^tm4.2Lyd and Pgr^tm1Bwo/Pgr^tm1Bwo mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:28980
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin cassette was inserted into the first exon and downstream from the initiating codons that encode the A and B isoforms to effectively disrupt transcription of both isoforms. Northern analysis indicated a lack of gene specific transcript. Competitive binding assays for the progesterone receptor indicated a lack a functional protein in homozygous mutant animals. (J:28980)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	17 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pgr^tm1Bwo

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Pgr Mutation:	75 strains or lines available

References

Original:	J:28980 Lydon JP, et al., Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 1995 Sep 15;9(18):2266-78
All:	72 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24