Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Ptentm1Ppp
Name:	phosphatase and tensin homolog; targeted mutation 1, Pier Paolo Pandolfi
MGI ID:	MGI:1857936
Synonyms:	PTEN-
Gene:	Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM
Alliance:	Ptentm1Ppp page

Germline Transmission:	Earliest citation of germline transmission: J:49532
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 4 and 5, which contain sequences encoding the phosphatase domain. (J:49532)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptentm1Ppp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	88 strains or lines available

Original:	J:49532 Di Cristofano A, et al., Pten is essential for embryonic development and tumour suppression. Nat Genet. 1998 Aug;19(4):348-55
All:	61 reference(s)