Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Ptentm1Mak Name: phosphatase and tensin homolog; targeted mutation 1, Tak W Mak MGI ID: MGI:1857937 Synonyms: mPTEN-, mPTEN3-5, Pten- Gene: Pten  Location: Chr19:32734977-32803560 bp, + strand  Genetic Position: Chr19, 28.14 cM Alliance: Ptentm1Mak page

Embryonic defects in Ptentm1Mak/Pten+ Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:50437
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing the splice donor site of exon 2 and exons 3-5. RT-PCR analysis on liver RNA from heterozygous mice demonstrated that an aberrant, smaller transcript was made from this allele, but no functional protein is predicted to be made. (J:50437)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

List all tumor models in MMHCdb carrying Ptentm1Mak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pten Mutation:	88 strains or lines available

Original:	J:50437 Suzuki A, et al., High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol. 1998 Oct 22;8(21):1169-78
All:	23 reference(s)