Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol: Tsc2tm1Djk Name: TSC complex subunit 2; targeted mutation 1, David J Kwiatkowski MGI ID: MGI:1857938 Synonyms: Tsc-, Tsc2- Gene: Tsc2  Location: Chr17:24814790-24851604 bp, - strand  Genetic Position: Chr17, 12.41 cM Alliance: Tsc2tm1Djk page

Small size and liver hypoplasia in Tsc2tm1Djk/Tsc2tm1Djk embryos Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:57631
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion     A neomycin cassette was inserted into the second coding exon of the gene. (J:57631)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Tsc2tm1Djk

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tsc2 Mutation:	78 strains or lines available

Original:	J:57631 Onda H, et al., Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest. 1999 Sep;104(6):687-95
All:	77 reference(s)