Msh2<tm1Mak> Targeted Allele Detail MGI Mouse (MGI:1857940)

Msh2^tm1Mak
Targeted Allele Detail

Summary

Symbol:	Msh2^tm1Mak
Name:	mutS homolog 2; targeted mutation 1, Tak W Mak
MGI ID:	MGI:1857940
Synonyms:	MSH2-
Gene:	Msh2 Location: Chr17:87979960-88031141 bp, + strand Genetic Position: Chr17, 57.87 cM
Alliance:	Msh2^tm1Mak page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:28397
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette was inserted in an antisense orientation in an exon of the gene that corresponded to exon 11 of the human gene, resulting in the deletion of 68 bp (1959 - 2026). Western blots of protein extracts from tail fibroblasts of homozygous mutant mice showed no detectable protein expressed for the targeted gene. (J:28397)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Msh2^tm1Mak

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Msh2 Mutation:	95 strains or lines available

References

Original:	J:28397 Reitmair AH, et al., MSH2 deficient mice are viable and susceptible to lymphoid tumours. Nat Genet. 1995 Sep;11(1):64-70
All:	58 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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