Cdkn2a<tm1Rdp> Targeted Allele Detail MGI Mouse (MGI:1857942)

Cdkn2a^tm1Rdp
Targeted Allele Detail

Summary

Symbol:	Cdkn2a^tm1Rdp
Name:	cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho
MGI ID:	MGI:1857942
Synonyms:	ARF-, Cdkn2a-, Cdkn2a^lox, ink4a-, INK4a-, Ink4a/arf-, Ink4a/Arf-, INK4a-Arf^-, Ink4a/Arf^KO, Ink4a-Arf-null, Inkdelta2/3 null, p16^INK4a-, p16^INK4a, p16-KO, p16p19^null
Gene:	Cdkn2a Location: Chr4:89192710-89212856 bp, - strand Genetic Position: Chr4, 42.15 cM, cytoband C3-C6
Alliance:	Cdkn2a^tm1Rdp page

Degenerative phenotypes, including increased apoptosis in gastrointestinal crypts and germ cell depletion, in Terc^tm1Rdp/Terc^tm1Rdp and Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:53805
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Exons E2 and E3 were deleted and replaced by a neomycin cassette. Note that both the p16^Ink4a and p19^ARF alternative splice transcripts are mutated in this allele. (J:53805)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background
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hm1	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	FVB.Cg-Cdkn2a^tm1Rdp
hm2	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	involves: 129/Sv * C57BL/6 * C57BL/6J * SJL
hm3	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	involves: 129/Sv * C57BL/6J * FVB/N * SJL
hm4	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL
hm5	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	involves: 129/Sv * C57BL/6 * SJL
cn6	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Rnf2^tm1Mvi/Rnf2^tm1Mvi Tg(Mx1-cre)1Cgn/0	involves: 129 * C57BL/6 * C57BL/10 * CBA * SJL
cn7	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺ Pdgfra^tm12Sor/Pdgfra⁺	involves: 129 * C57BL/6J * SJL
cn8	Braf^tm1Cpri/Braf^tm1Cpri Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-cre/ERT2)1Lru/0	involves: 129/Sv * 129P2/OlaHsd * C57BL/6 * DBA/2 * SJL
cn9	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(CAG-Bgeo,-tTA,-EGFP)2A11Kuw/0 Tg(Pdx1-cre)6Tuv/0 Tg(tetO-MYC)36Bop/0	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * FVB/N * SJL
cn10 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Pten^tm1Rps/Pten^tm1Rps Tg(Tyr-cre/ERT2)13Bos/0	involves: 129/Sv * 129S1/Sv * C57BL/6J * FVB/N * SJL
cn11	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Kras^tm4Tyj/Kras⁺	involves: 129/Sv * 129S4/SvJae * C57BL/6 * FVB/N * SJL
cn12 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR*)Char} Pten^tm1Hwu/Pten^tm1Hwu	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
cn13 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm1(CAG-EGFR)Char}/Col1a1^{tm1(CAG-EGFR)Char} Pten^tm1Hwu/Pten^tm1Hwu	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
cn14 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Col1a1^{tm2(CAG-EGFR)Char}/Col1a1^{tm2(CAG-EGFR)Char} Pten^tm1Hwu/Pten^tm1Hwu	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
cn15	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp E4f1^tm1Pisc/E4f1^tm1.1Llca Polr2a^{tm1(cre/ERT2)Bbd}/Polr2a⁺	involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL
cn16	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Dicer1^tm1Snj/Dicer1^tm1Snj	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
cn17	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp X/Tg(Tyr-HRAS)60Lc	involves: 129/Sv * C57BL/6J * CBA/J * SJL
cn18 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Pten^tm1Rps/Pten^tm1Rps Tg(Tyr-cre/ERT2)13Bos/0	involves: 129/Sv * C57BL/6J * FVB * SJL
cn19	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Gt(ROSA)26Sor^{tm1(rtTA,EGFP)Nagy}/Gt(ROSA)26Sor⁺ Pten^tm1Rdp/Pten^tm1Rdp Tg(tetO-BRAF*V600E)29Lc/0 Tg(Tyr-cre/ERT2)13Bos/0	involves: 129/Sv * C57BL/6J * FVB * SJL
cx20	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Fbxw11^tm1Nakay/Fbxw11^tm1Nakay	B6.Cg-Cdkn2a^tm1Rdp Fbxw11^tm1Nakay
cx21	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc/0 Tg(Tyr-rtTA)37Lc/0	FVB.Cg-Cdkn2a^tm1Rdp Tg(tetO-Nras*Q61K)#Lc Tg(Tyr-rtTA)37Lc
cx22	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(GFAP-TVA)10Ech/0	involves: 129 * BALB/c * C57BL/6 * FVB/N * SJL
cx23	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(NES-TVA)J12Ech/0	involves: 129 * C57BL/6 * FVB/N * SJL
cx24	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(NES-TVA)J12Ech/0	involves: 129 * C57BL/6 * FVB/N * SJL
cx25	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Scgb1a1-rtTA)1Jaw/0 Tg(tetO-Kras2)12Hev/0	involves: 129 * C57BL/6J * FVB/N * SJL
cx26	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Rnf2^tm1Mvl/Rnf2^tm1Mvl	involves: 129P2/Ola * 129/Sv * C57BL/6J * FVB/N * SJL
cx27	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL
cx28	Cdkn2a^tm1Rdp/Cdkn2a⁺ Nf1^tm1Tyj/Nf1⁺	involves: 129S2/SvPas * 129S6/SvEvTac
cx29 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Nf1^tm1Tyj/Nf1⁺	involves: 129S2/SvPas * 129S6/SvEvTac
cx30	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	involves: 129/Sv * 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
cx31	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Lig4^tm1Fwa/Lig4^tm1Fwa	involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL
cx32	Cdkn2a^tm1Rdp/Cdkn2a⁺ Lig4^tm1Fwa/Lig4^tm1Fwa	involves: 129/Sv * 129S6/SvEvTac * C57BL/6J * SJL
cx33	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Dicer1^tm1Snj/Dicer1^tm1Snj	involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * SJL
cx34	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(GFAP-TVA)5Hev/0	involves: 129/Sv * BALB/c * C57BL/6 * FVB/N * SJL
cx35 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/?	involves: 129/Sv * C57BL/6 * DBA/2 * SJL
cx36 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(Tyr-NRAS*Q61K)1Bee/?	involves: 129/Sv * C57BL/6 * DBA/2 * SJL
cx37 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(NES-TVA)J12Ech/0	involves: 129/Sv * C57BL/6 * FVB/N * SJL
cx38 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a⁺ X/Tg(Tyr-HRAS)60Lc	involves: 129/Sv * C57BL/6J * CBA/J * FVB/N * SJL
cx39 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-BRAF*V600E)470Fgh/0	involves: 129/Sv * C57BL/6J * CBA * SJL
cx40 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-BRAF*V600E)476Fgh/0	involves: 129/Sv * C57BL/6J * CBA * SJL
cx41 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(S100b-v-erbB)4496Waw/0	involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
cx42 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(S100b-v-erbB)4496Waw/0	involves: 129/Sv * C57BL/6J * DBA/2J * FVB/N * SJL
cx43	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129/Sv * C57BL/6J * DBA/2 * SJL
cx44 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Mt1-Hgf)19Lmb/0	involves: 129/Sv * C57BL/6J * FVB/N * SJL
cx45	Cdkn2a^tm1Rdp/Cdkn2a⁺ Terc^tm1Rdp/Terc^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL
cx46 Disease Model	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(tetO-BRAF*V600E)29Lc/0 Tg(Tyr-rtTA)37Lc/0	involves: 129/Sv * C57BL/6J * SJL
cx47	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Mxi1^tm1Rdp/Mxi1^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL
cx48	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Terc^tm1Rdp/Terc^tm1Rdp	involves: 129/Sv * C57BL/6J * SJL
cx49	Cav1^tm1Mls/Cav1^tm1Mls Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp	involves: 129/Sv * C57BL/6 * SJL

Phenotypes:

Affected Systems	hm1	hm2	hm3	hm4	hm5	cn6	cn7	cn8	cn9	cn10	cn11	cn12	cn13	cn14	cn15	cn16	cn17	cn18	cn19	cx20	cx21	cx22	cx23	cx24	cx25	cx26	cx27	cx28	cx29	cx30	cx31	cx32	cx33	cx34	cx35	cx36	cx37	cx38	cx39	cx40	cx41	cx42	cx43	cx44	cx45	cx46		cx47	cx48		cx49
show or hide all annotated terms Sex:
behavior/neurological																																							√
paralysis																																							√
cellular		√	√		√											N														√	√	√	√																√	√	√	√
cellular phenotype																N
abnormal telomere length																																																	√	√
abnormal cell physiology		√	√																											√
abnormal cell cycle					√																																														√	√
increased cellular sensitivity to ionizing radiation																																√
increased male germ cell apoptosis																																																		√
increased neuron apoptosis																																√
decreased cell proliferation																															√	√																	√	√
increased cell proliferation																																	√
increased fibroblast proliferation					√																																														√	√
increased keratinocyte proliferation																														√
delayed cellular replicative senescence		√																												√
digestive/alimentary system							√																																										√	√
abnormal intestine morphology																																																	√	√
intestinal fibrosis							√
embryo																				√						√
embryonic growth arrest																				√						√
embryonic growth retardation																				√
abnormal somite development																										√
endocrine/exocrine glands									√																																						√			√	√
abnormal mammary gland duct morphology																																																			√
abnormal branching of the mammary ductal tree																																																			√
mammary gland duct hyperplasia																																																			√
prostate gland hyperplasia																																															√
increased prostate gland adenocarcinoma incidence																																															√
increased pancreas tumor incidence									√
increased pancreatic ductal adenocarcinoma incidence									√
testicular atrophy																																																		√
abnormal prostate gland physiology																																															√
growth/size/body						√														√																													√	√
embryonic growth retardation																				√
decreased body size																																																	√	√
decreased body weight																																																	√	√
enlarged liver						√
enlarged spleen						√
hematopoietic system					√	√
hematopoietic system phenotype						N
abnormal common myeloid progenitor cell morphology						√
extramedullary hematopoiesis					√
abnormal spleen morphology					√
enlarged spleen						√
abnormal spleen red pulp morphology					√
increased spleen white pulp amount					√
homeostasis/metabolism								√
increased incidence of tumors by chemical induction								√
immune system					√	√																													√
abnormal spleen morphology					√
enlarged spleen						√
abnormal spleen red pulp morphology					√
increased spleen white pulp amount					√
enlarged lymph nodes																																			√
integument		√			√		√	√							√						√									√					√	√							√								√
abnormal mammary gland duct morphology																																																			√
abnormal branching of the mammary ductal tree																																																			√
mammary gland duct hyperplasia																																																			√
hyperkeratosis															√
epidermal hyperplasia															√
skin lesions																																											√
abnormal skin development																														√
increased skin tumor incidence								√
increased cutaneous melanoma incidence					√																√														√	√							√
skin fibrosis							√
abnormal skin physiology		√																												√
abnormal keratinocyte physiology		√													√															√
increased keratinocyte proliferation																														√
liver/biliary system						√
enlarged liver						√
mortality/aging			√			√			√		√	√	√	√			√			√									√		√	√		√			√		√	√	√					√	√		√	√
premature death						√					√																		√					√			√		√	√	√					√	√
decreased tumor-free survival time			√						√			√	√	√			√
prenatal lethality, complete penetrance																															√	√
embryonic lethality during organogenesis, complete penetrance																				√
premature aging																																																	√	√
muscle							√																																					√
abnormal myogenesis																																												√
increased satellite cell number																																												√
skeletal muscle interstitial fibrosis							√
increased rhabdomyosarcoma incidence																																												√
neoplasm		√	√	√	√	√	√	√	√	√	√	√	√	√			√	√	√		√	√	√	√	√		N	√	√	√				√	√	√	√	√	√	√	√	√	√	√	√		√	√	√	√
neoplasm																											N
increased metastatic potential									√																										√
decreased tumor growth/size																	√
increased tumor incidence			√		√																																							√	√			√	√	√
increased prostate gland adenocarcinoma incidence																																															√
increased pancreas tumor incidence									√
increased pancreatic ductal adenocarcinoma incidence									√
increased incidence of tumors by chemical induction								√
increased skin tumor incidence								√
increased cutaneous melanoma incidence					√																√														√	√							√
increased leukemia incidence																													√
increased lymphoma incidence			√			√																							√																√				√	√
increased B cell derived lymphoma incidence					√
increased squamous cell carcinoma incidence		√																												√
increased melanoma incidence								√		√							√	√	√																				√	√				√
increased intraocular melanoma incidence																																						√
increased sarcoma incidence			√		√		√																																						√				√	√
increased rhabdomyosarcoma incidence																																												√
increased fibrosarcoma incidence					√		√
increased neurofibrosarcoma incidence																												√	√
increased hemangiosarcoma incidence					√
increased incidence of tumors by UV-induction																																						√
increased brain tumor incidence				√
increased glioma incidence																						√	√	√										√			√				√	√
increased glioblastoma incidence												√	√	√
increased oligodendroglioma incidence																																		√			√				√
increased lung tumor incidence																									√
increased lung adenocarcinoma incidence											√														√
decreased tumor latency																																									√
nervous system	√			√								√	√	√								√	√	√		√		√	√			√		√			√		√		√	√
nervous system phenotype																													N
increased neuron apoptosis																																√
increased neurofibrosarcoma incidence																												√	√
increased brain tumor incidence				√
increased glioma incidence																						√	√	√										√			√				√	√
increased glioblastoma incidence												√	√	√
increased oligodendroglioma incidence																																		√			√				√
abnormal forebrain development																										√
hydrocephaly																						√	√																√
abnormal retina photoreceptor morphology	√
pigmentation																											N																√
pigmentation phenotype																											N
hyperpigmentation																																											√
reproductive system																																															√			√
increased male germ cell apoptosis																																																		√
prostate gland hyperplasia																																															√
increased prostate gland adenocarcinoma incidence																																															√
testicular atrophy																																																		√
abnormal prostate gland physiology																																															√
respiratory system											√														√
increased lung tumor incidence																									√
increased lung adenocarcinoma incidence											√														√
skeleton																																																	√	√
kyphosis																																																	√	√
vision/eye	√																																					√
increased intraocular melanoma incidence																																						√
abnormal lens development	√
cataract	√																																					√
microphthalmia	√
abnormal posterior eye segment morphology	√
persistent hyperplastic primary vitreous	√
abnormal retina neuronal layer morphology	√
abnormal retina photoreceptor morphology	√
retina fold	√

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Key:

√

disease model

expected model not found

Models:

Human Diseases	cn10	cn12	cn13	cn14	cn18	cx29	cx35	cx36	cx37	cx38	cx39	cx40	cx41	cx42	cx44	cx46
dysplastic nevus syndrome IDs dysplastic nevus syndrome DOID:10041 MESH:D004416 UMLS_CUI:C0205747 Close
high grade glioma IDs high grade glioma DOID:3070 DOID:2627 KEGG:05214 MESH:D005910 NCI:C3059 NCI:C4822 OMIM:PS137800 ORDO:182067 UMLS_CUI:C0017638 UMLS_CUI:C0555198 Close		√	√	√
malignant peripheral nerve sheath tumor IDs malignant peripheral nerve sheath tumor DOID:5940 MESH:D018319 NCI:C3798 UMLS_CUI:C0751690 Close						√
melanoma IDs melanoma DOID:1909 EFO:0000756 KEGG:05218 MESH:D008545 NCI:C3224 UMLS_CUI:C0025202 Close	√				√						√	√
oligodendroglioma IDs oligodendroglioma DOID:3181 DOID:3182 MESH:D009837 NCI:C3288 UMLS_CUI:C0751396 Close									√				√	√
prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358 Close																√
rhabdomyosarcoma IDs rhabdomyosarcoma DOID:3247 MESH:D012208 NCI:C3359 UMLS_CUI:C0035412 Close															√
skin melanoma IDs skin melanoma DOID:8923 DOID:0050609 DOID:10043 DOID:10046 DOID:10051 DOID:10052 DOID:10055 DOID:8922 ICD10CM:C43.9 ICD9CM:172 ICD9CM:172.0 ICD9CM:172.2 ICD9CM:172.4 ICD9CM:172.5 ICD9CM:172.9 MESH:D000096142 NCI:C3510 OMIM:608035 OMIM:612263 UMLS_CUI:C0151779 Close							√	√
uveal melanoma IDs uveal melanoma DOID:6039 MESH:C536494 NCI:C7712 OMIM:155720 OMIM:606660 OMIM:606661 ORDO:39044 UMLS_CUI:C0220633 Close										√

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdkn2a^tm1Rdp

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:	66 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome in Orthologous Human Gene: human supratentorial ependymoma subgroup in homozygous mice (J:163931)

References

Original:	J:53805 Serrano M, et al., Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 5;85(1):27-37
All:	348 reference(s)

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