Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | Notes | References

Symbol: Cdkn2atm1Rdp Name: cyclin dependent kinase inhibitor 2A; targeted mutation 1, Ronald DePinho MGI ID: MGI:1857942 Synonyms: ARF-, Cdkn2a-, Cdkn2alox, ink4a-, INK4a-, Ink4a/arf-, Ink4a/Arf-, INK4a-Arf-, Ink4a/ArfKO, Ink4a-Arf-null, Inkdelta2/3 null, p16INK4a-, p16INK4a, p16-KO, p16p19null Gene: Cdkn2a  Location: Chr4:89192710-89212856 bp, - strand  Genetic Position: Chr4, 42.15 cM, cytoband C3-C6 Alliance: Cdkn2atm1Rdp page

Degenerative phenotypes, including increased apoptosis in gastrointestinal crypts and germ cell depletion, in Terctm1Rdp/Terctm1Rdp and Cdkn2atm1Rdp/Cdkn2atm1Rdp Terctm1Rdp/Terctm1Rdp mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:53805
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons E2 and E3 were deleted and replaced by a neomycin cassette. Note that both the p16Ink4a and p19ARF alternative splice transcripts are mutated in this allele. (J:53805)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdkn2atm1Rdp

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Cdkn2a Mutation:	67 strains or lines available

Original:	J:53805 Serrano M, et al., Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 5;85(1):27-37
All:	345 reference(s)