Mlh1<tm1Lisk> Targeted Allele Detail MGI Mouse (MGI:1857946)

Mlh1^tm1Lisk
Targeted Allele Detail

Summary

Symbol:	Mlh1^tm1Lisk
Name:	mutL homolog 1; targeted mutation 1, Michael Liskay
MGI ID:	MGI:1857946
Synonyms:	Mlh1-
Gene:	Mlh1 Location: Chr9:111057296-111100854 bp, - strand Genetic Position: Chr9, 60.92 cM
Alliance:	Mlh1^tm1Lisk page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:34291
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1^b-m2

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Replacement of exon 4 with a Pgk-HPRT mini-gene. (J:34291)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Mlh1^tm1Lisk

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available Cell Lines: 0 lines available
Carrying any Mlh1 Mutation:	44 strains or lines available

References

Original:	J:34291 Baker SM, et al., Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over [see comments]. Nat Genet. 1996 Jul;13(3):336-42
All:	50 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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