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Lbptm1Buru
Targeted Allele Detail
Summary
Symbol: Lbptm1Buru
Name: lipopolysaccharide binding protein; targeted mutation 1, Boston University School of Medicine
MGI ID: MGI:1857975
Synonyms: LBP-
Gene: Lbp  Location: Chr2:158148413-158174772 bp, + strand  Genetic Position: Chr2, 78.72 cM
Alliance: Lbptm1Buru page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:44878
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced all of the first exon, including the translational start site, and part of the first intron. RT-PCR on liver and kidney samples from homozygous mutant mice showed very little transcript and no transcript, respectively, for the targeted gene in these organs. (J:44878)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lbp Mutation:  30 strains or lines available
References
Original:  J:44878 Wurfel MM, et al., Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact. J Exp Med. 1997 Dec 15;186(12):2051-6
All:  13 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory