Grik2tm1Sfh
Targeted Allele Detail
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| Symbol: |
Grik2tm1Sfh |
| Name: |
glutamate receptor, ionotropic, kainate 2 (beta 2); targeted mutation 1, Stephen F Heinemann |
| MGI ID: |
MGI:1857979 |
| Synonyms: |
GLUK6-, GluR6- |
| Gene: |
Grik2 Location: Chr10:48970929-49664862 bp, - strand Genetic Position: Chr10, 24.87 cM
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| Alliance: |
Grik2tm1Sfh page
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced a 687 bp fragment of the gene, which contained the exon encoding MD2. In situ hybridization of parasagittal sections of brains from homozygous mutant mice probed with gene-specific probes showed no detectable mRNA for the targeted gene. Immunoblots of hippocampal membrane extracts from homozygous mutant mice using antibodies against the targeted protein showed no detectable protein.
(J:46932)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Grik2 Mutation: |
65 strains or lines available
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| Original: |
J:46932 Mulle C, et al., Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature. 1998 Apr 9;392(6676):601-5 |
| All: |
39 reference(s) |
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Analysis Tools
