Grm2tm1Nak
Targeted Allele Detail
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| Symbol: |
Grm2tm1Nak |
| Name: |
glutamate receptor, metabotropic 2; targeted mutation 1, Shigetada Nakanishi |
| MGI ID: |
MGI:1857988 |
| Synonyms: |
mGluR2 - |
| Gene: |
Grm2 Location: Chr9:106521733-106533308 bp, - strand Genetic Position: Chr9, 57.98 cM
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| Alliance: |
Grm2tm1Nak page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:34606
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| Parent Cell Line: |
CCE/EK.CCE (ES Cell)
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| Strain of Origin: |
129S/SvEv-Gpi1c
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette replaced the translation initiation site and its downstream sequence in exon 2. Northern blot analysis and western blot analysis confirmed the absence of expression from this allele (data not shown). Immunocytochemical studies did not detect protein in hippocampal coronal sections of homozygous mutant adult mice.
(J:34606)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:34606 Yokoi M, et al., Impairment of hippocampal mossy fiber LTD in mice lacking mGluR2. Science. 1996 Aug 2;273(5275):645-7 |
| All: |
22 reference(s) |
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Analysis Tools
