Msh6<tm1Rak> Targeted Allele Detail MGI Mouse (MGI:1858014)

Msh6^tm1Rak
Targeted Allele Detail

Summary

Symbol:	Msh6^tm1Rak
Name:	mutS homolog 6; targeted mutation 1, Raju Kucherlapati
MGI ID:	MGI:1858014
Synonyms:	Msh6-
Gene:	Msh6 Location: Chr17:88282490-88298320 bp, + strand Genetic Position: Chr17, 57.87 cM
Alliance:	Msh6^tm1Rak page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:44428
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: A neomycin resistance gene was inserted at codon 336 within exon 4 of the gene, resulting in a stop codon 21 nucleotides downstream. No transcript for the targeted gene was detected on Northern blots of RNA extracted from two double-targeted ES cell lines. No protein product for the targeted gene was detected on Western blots of protein extracted from two double-targeted ES cell lines. (J:44428)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

Tumor Data

List all tumor models in MMHCdb carrying Msh6^tm1Rak

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Msh6 Mutation:	52 strains or lines available

References

Original:	J:44428 Edelmann W, et al., Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell. 1997 Nov 14;91(4):467-77
All:	26 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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