Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Mlh1tm1Rak
Name:	mutL homolog 1; targeted mutation 1, Raju Kucherlapati
MGI ID:	MGI:1858054
Synonyms:	mlh1-, Mlh1-, Mlh1delta
Gene:	Mlh1  Location: Chr9:111057296-111100854 bp, - strand  Genetic Position: Chr9, 60.92 cM
Alliance:	Mlh1tm1Rak page

Germline Transmission:	Earliest citation of germline transmission: J:33878
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     Replacement of exon 2 and flanking intronic sequence with a neomycin cassette. (J:33878)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

List all tumor models in MMHCdb carrying Mlh1tm1Rak

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mlh1 Mutation:	44 strains or lines available

Original:	J:33878 Edelmann W, et al., Meiotic pachytene arrest in MLH1-deficient mice. Cell. 1996 Jun 28;85(7):1125-34
All:	40 reference(s)