Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Fechm1Pas
Name:	ferrochelatase; ferrochelatase deficiency, mutation 1, Institut Pasteur
MGI ID:	MGI:1858114
Synonyms:	fch
Gene:	Fech  Location: Chr18:64589613-64622169 bp, - strand  Genetic Position: Chr18, 37.43 cM
Alliance:	Fechm1Pas page

Strain of Origin:

129/Sv x BALB/c

Allele Type:    Chemically induced (ENU) Mutation:    Single point mutation   Mutation details: This mutation is a T-to-A transversion at position 293, resulting in a methionine to lysine substitution at position 98 of the encoded protein. (J:12757) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

List all tumor models in MMHCdb carrying Fechm1Pas

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fech Mutation:	24 strains or lines available

Original:	J:2021 Tutois S, et al., Erythropoietic protoporphyria in the house mouse. A recessive inherited ferrochelatase deficiency with anemia, photosensitivity, and liver disease. J Clin Invest. 1991 Nov;88(5):1730-6
All:	21 reference(s)