Sart3 MGI Mouse Gene Detail - MGI:1858230 - squamous cell carcinoma antigen recognized by T cells 3

Symbol

Sart3
Name

squamous cell carcinoma antigen recognized by T cells 3

Feature Type

protein coding gene
IDs

MGI:1858230
NCBI Gene: 53890
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:113880505-113910461 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 55.55 cM
Mapping Data

3 experiments

SNPs within 2kb

847 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858230	protein coding gene	Chr5:113880505-113910571 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029922	protein coding gene	Chr5:116418141-116450491 (-)
A/J	MGP_AJ_G0029887	protein coding gene	Chr5:111859262-111889373 (-)
AKR/J	MGP_AKRJ_G0029825	protein coding gene	Chr5:115407047-115438588 (-)
BALB/cJ	MGP_BALBcJ_G0029898	protein coding gene	Chr5:113231066-113261827 (-)
C3H/HeJ	MGP_C3HHeJ_G0029618	protein coding gene	Chr5:115897165-115929616 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030352	protein coding gene	Chr5:120939638-120970823 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027580	protein coding gene	Chr5:106686623-106719053 (-)
CAST/EiJ	MGP_CASTEiJ_G0029026	protein coding gene	Chr5:114821296-114852489 (-)
CBA/J	MGP_CBAJ_G0029585	protein coding gene	Chr5:125498355-125532064 (-)
DBA/2J	MGP_DBA2J_G0029735	protein coding gene	Chr5:111924101-111954768 (-)
FVB/NJ	MGP_FVBNJ_G0029692	protein coding gene	Chr5:110697903-110734145 (-)
LP/J	MGP_LPJ_G0029824	protein coding gene	Chr5:116989296-117020438 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029723	protein coding gene	Chr5:130004356-130036898 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030393	protein coding gene	Chr5:114859427-114890509 (-)
PWK/PhJ	MGP_PWKPhJ_G0028740	protein coding gene	Chr5:110550285-110580175 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028578	protein coding gene	Chr5:112389215-112420310 (-)
WSB/EiJ	MGP_WSBEiJ_G0029102	protein coding gene	Chr5:115421091-115451311 (-)

Human Ortholog

SART3, spliceosome associated factor 3, U4/U6 recycling protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SART3, spliceosome associated factor 3, U4/U6 recycling protein
Synonyms

DSAP1, P100, p110, p110(nrb), RP11-13G14, TIP110
Links

HGNC:16860

NCBI Gene ID: 9733

neXtProt AC: NX_Q15020

UniProt: Q15020
Chr Location

12q23.3; chr12:108522214-108561400 (-) GRCh38

MGI Vertebrate Homology

Sart3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SART3
Gene Tree

Sart3

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Phenotype Summary

9 phenotypes from 2 alleles in 3 genetic backgrounds
1 images
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

8
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Sart3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

46 strains or lines available

Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. In vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture.

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All GO Annotations

41
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

69
cDNA Data

146
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase sart3

ZFIN sart3

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All Sequences

53
RefSeq

11
UniProt

1
CCDS

CCDS19552.1

Ensembl

ENSMUSG00000018974 (Evidence)
NCBI Gene

53890

			Length	Strain/Species	Flank
genomic	53890	NCBI Gene Model \| MGI Sequence Detail	29957	C57BL/6J	± kb
transcript	NM_001356621	RefSeq \| MGI Sequence Detail	4393	C57BL/6
polypeptide	Q9JLI8	UniProt \| EBI \| MGI Sequence Detail	962	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014462 squamous cell carcinoma antigen recognized by T-cells 3

(term hierarchy)
InterPro Domains

IPR003107 HAT (Half-A-TPR) repeat

IPR008669 LSM-interacting domain

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034217 SART3, RNA recognition motif 1

IPR034218 SART3, RNA recognition motif 2

IPR008847 Suppressor of forked

IPR011990 Tetratricopeptide-like helical domain superfamily

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All nucleic 149

cDNA 147

Primer pair 2

Microarray probesets 3

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MGI:2141094

Summaries

All 42

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 18
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Sart3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr52652	Chr5:113910696-113910767 (-)	-271 bp
Tssr52651	Chr5:113909704-113909720 (-)	749 bp
Tssr52650	Chr5:113883249-113883258 (-)	27,207 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24