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Mpp2 Gene Detail
Summary
  • Symbol
    Mpp2
  • Name
    membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
  • Synonyms
    D11Bwg0652e, Dlg2, Dlgh2, Pals4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858257
    NCBI Gene: 50997
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101947841-101979341 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1012 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858257
 protein coding gene Chr11:101947841-101979464 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019219
 protein coding gene Chr11:105000574-105032207 (-)
A/J MGP_AJ_G0019187
 protein coding gene Chr11:100567753-100600004 (-)
AKR/J MGP_AKRJ_G0019156
 protein coding gene Chr11:103683288-103714731 (-)
BALB/cJ MGP_BALBcJ_G0019161
 protein coding gene Chr11:101053177-101084587 (-)
C3H/HeJ MGP_C3HHeJ_G0018970
 protein coding gene Chr11:103886397-103919328 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019610
 protein coding gene Chr11:108274583-108307677 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017236
 protein coding gene Chr11:97992886-98025353 (-)
CAST/EiJ MGP_CASTEiJ_G0018524
 protein coding gene Chr11:104854819-104889215 (-)
CBA/J MGP_CBAJ_G0018939
 protein coding gene Chr11:112744837-112781292 (-)
DBA/2J MGP_DBA2J_G0019051
 protein coding gene Chr11:100094216-100125645 (-)
FVB/NJ MGP_FVBNJ_G0019041
 protein coding gene Chr11:99622072-99653386 (-)
LP/J MGP_LPJ_G0019120
 protein coding gene Chr11:105518513-105551061 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019072
 protein coding gene Chr11:112271374-112302827 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019648
 protein coding gene Chr11:104046197-104077736 (-)
PWK/PhJ MGP_PWKPhJ_G0018287
 protein coding gene Chr11:101156104-101188164 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018079
 protein coding gene Chr11:103800323-103832930 (-)
WSB/EiJ MGP_WSBEiJ_G0018573
 protein coding gene Chr11:104027635-104068400 (-)



Homology
more
  • Human Ortholog
    MPP2, MAGUK p55 scaffold protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MPP2, MAGUK p55 scaffold protein 2
  • Synonyms
    DLG2
  • Links
    NCBI Gene ID: 4355
    neXtProt AC: NX_Q14168
    UniProt: Q14168

  • Chr Location
    17q21.31; chr17:43875357-43909711 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    32
  • cDNA Data
    34
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017314 Ensembl Gene Model | MGI Sequence Detail 31501 C57BL/6J ±  kb
    transcript ENSMUST00000100398 Ensembl | MGI Sequence Detail 3577 Not Applicable  
    polypeptide ENSMUSP00000097967 Ensembl | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 35
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-34058, MGI:106365
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:37257 Elder B, et al., cDNA sequence and genomic structure of the murine p55 (Mpp1) gene. Genomics. 1996 Dec 1;38(2):231-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory