Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Rag2tm1Fwa
Name:	recombination activating gene 2; targeted mutation 1, Frederick W Alt
MGI ID:	MGI:1858556
Synonyms:	Rag2-, RAG-2-, RAG2 KO, Rag2M, Rag2tm1Alt, Rag2tm1Fwe
Gene:	Rag2  Location: Chr2:101455063-101462874 bp, + strand  Genetic Position: Chr2, 53.87 cM
Alliance:	Rag2tm1Fwa page

Germline Transmission:	Earliest citation of germline transmission: J:1935
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a 0.85kb segment of the open reading frame, eliminating the encoding of 286 of the 527 amino acids of the protein. (J:1935)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	19 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	10 anatomical structure(s)

List all tumor models in MMHCdb carrying Rag2tm1Fwa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 45 strains available      Cell Lines: 0 lines available
Carrying any Rag2 Mutation:	119 strains or lines available

Original:	J:1935 Shinkai Y, et al., RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992 Mar 6;68(5):855-67
All:	993 reference(s)