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Keap1 Gene Detail
Summary
  • Symbol
    Keap1
  • Name
    kelch-like ECH-associated protein 1
  • Synonyms
    INrf2, mKIAA0132, ring canal protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858732
    NCBI Gene: 50868
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21141026-21150628 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.74 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858732
 protein coding gene Chr9:21141026-21150657 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034444
 protein coding gene Chr9:18423211-18432813 (-)
A/J MGP_AJ_G0034422
 protein coding gene Chr9:18115511-18125113 (-)
AKR/J MGP_AKRJ_G0034349
 protein coding gene Chr9:18442828-18452430 (-)
BALB/cJ MGP_BALBcJ_G0034413
 protein coding gene Chr9:18007571-18017173 (-)
C3H/HeJ MGP_C3HHeJ_G0034125
 protein coding gene Chr9:18752176-18761778 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034934
 protein coding gene Chr9:19164527-19174129 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031864
 protein coding gene Chr9:17241341-17251001 (-)
CAST/EiJ MGP_CASTEiJ_G0033448
 protein coding gene Chr9:18580540-18590147 (-)
CBA/J MGP_CBAJ_G0034098
 protein coding gene Chr9:19890213-19899821 (-)
DBA/2J MGP_DBA2J_G0034257
 protein coding gene Chr9:18089869-18099471 (-)
FVB/NJ MGP_FVBNJ_G0034200
 protein coding gene Chr9:17617037-17626884 (-)
LP/J MGP_LPJ_G0034342
 protein coding gene Chr9:18598281-18608103 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034243
 protein coding gene Chr9:21493259-21505016 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034954
 protein coding gene Chr9:18402983-18412585 (-)
PWK/PhJ MGP_PWKPhJ_G0033154
 protein coding gene Chr9:18071100-18080691 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032988
 protein coding gene Chr9:18453245-18462723 (-)
WSB/EiJ MGP_WSBEiJ_G0033563
 protein coding gene Chr9:18125282-18135051 (-)



Homology
more
  • Human Ortholog
    KEAP1, kelch like ECH associated protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KEAP1, kelch like ECH associated protein 1
  • Synonyms
    INrf2, KLHL19
  • Links
    NCBI Gene ID: 9817
    neXtProt AC: NX_Q14145
    UniProt: Q14145

  • Chr Location
    19p13.2; chr19:10486125-10503558 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KEAP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    132 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit scaly skin, hyperkeratosis of the esophagus and stomach mucosa, and die around 3 weeks of age, putatively due to malnutrition resulting from the abnormal alimentary epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    140
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 50868 NCBI Gene Model | MGI Sequence Detail 9603 C57BL/6J ±  kb
    transcript NM_016679 RefSeq | MGI Sequence Detail 4470 C57BL/6  
    polypeptide Q9Z2X8 UniProt | EBI | MGI Sequence Detail 624 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 140

      Microarray probesets 4
    References
    more
    • Summaries
      All 223
      Developmental Gene Expression 8
      Gene Ontology 23
      Phenotypes 132
    • Earliest
      J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
    • Latest
      J:349405 Dong W, et al., Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2. Exp Mol Med. 2024 Apr;56(4):946-958
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory