Arhgef5 MGI Mouse Gene Detail - MGI:1858952 - Rho guanine nucleotide exchange factor 5

Symbol

Arhgef5
Name

Rho guanine nucleotide exchange factor 5
Synonyms

2210412D05Rik

Feature Type

protein coding gene
IDs

MGI:1858952
NCBI Gene: 54324
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr6:43242578-43266250 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 21.15 cM
Mapping Data

4 experiments

SNPs within 2kb

771 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858952	protein coding gene	Chr6:43242516-43266254 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030676	protein coding gene	Chr6:41895100-41918824 (+)
A/J	MGP_AJ_G0030649	protein coding gene	Chr6:40049767-40073507 (+)
AKR/J	MGP_AKRJ_G0030574	protein coding gene	Chr6:41380079-41403819 (+)
BALB/cJ	MGP_BALBcJ_G0030659	protein coding gene	Chr6:40340606-40364338 (+)
C3H/HeJ	MGP_C3HHeJ_G0030372	protein coding gene	Chr6:41392658-41416394 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031113	protein coding gene	Chr6:42897278-42924335 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028320	protein coding gene	Chr6:37952750-37977585 (+)
CAST/EiJ	MGP_CASTEiJ_G0029776	protein coding gene	Chr6:41156984-41180936 (+)
CBA/J	MGP_CBAJ_G0030347	protein coding gene	Chr6:44642203-44665917 (+)
DBA/2J	MGP_DBA2J_G0030496	protein coding gene	Chr6:39925778-39949492 (+)
FVB/NJ	MGP_FVBNJ_G0030447	protein coding gene	Chr6:39641224-39664948 (+)
LP/J	MGP_LPJ_G0030580	protein coding gene	Chr6:41862558-41886287 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030482	protein coding gene	Chr6:46965060-46988736 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031143	protein coding gene	Chr6:41319518-41343235 (+)
PWK/PhJ	MGP_PWKPhJ_G0029488	protein coding gene	Chr6:39466608-39490444 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029324	protein coding gene	Chr6:40853013-40877012 (+)
WSB/EiJ	MGP_WSBEiJ_G0029852	protein coding gene	Chr6:41280669-41304411 (+)

Human Ortholog

ARHGEF5, Rho guanine nucleotide exchange factor 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARHGEF5, Rho guanine nucleotide exchange factor 5
Synonyms

GEF5, P60, TIM, TIM1
Links

HGNC:13209

NCBI Gene ID: 7984

neXtProt AC: NX_Q12774

UniProt: Q12774
Chr Location

7q35; chr7:144355288-144380632 (+) GRCh38

MGI Vertebrate Homology

Arhgef5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARHGEF5
Gene Tree

Arhgef5

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

3
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

72 strains or lines available

Mice homozygous for a knock-out allele exhibit decreased Th2 response in an ovalbumin-induced asthma model.

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All GO Annotations

35
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

3
cDNA Data

61
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arhgef5

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All Sequences

51
RefSeq

4
UniProt

3
CCDS

CCDS51759.1

Ensembl

ENSMUSG00000033542 (Evidence)
NCBI Gene

54324

			Length	Strain/Species	Flank
genomic	54324	NCBI Gene Model \| MGI Sequence Detail	23673	C57BL/6J	± kb
transcript	NM_133674	RefSeq \| MGI Sequence Detail	5403	C57BL/6
polypeptide	E9Q7D5	UniProt \| EBI \| MGI Sequence Detail	1581	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004258 Rho guanine nucleotide exchange factor 5

(term hierarchy)
InterPro Domains

IPR000219 Dbl homology (DH) domain

IPR035899 Dbl homology (DH) domain superfamily

IPR047271 Ephexin-like

IPR047270 Ephexin-like, PH domain

IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR029212 Rho guanine nucleotide exchange factor 5/35, N-terminal

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily
GlyGen

E9Q7D5 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)

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All nucleic 62

Genomic 1

cDNA 61

Microarray probesets 4

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MGI:1919632, MGI:2141687

Summaries

All 46

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 14
Earliest

J:62157 Thomas JW, et al., Comparative genome mapping in the sequence-based era: early experience with human chromosome 7. Genome Res. 2000 May;10(5):624-33
Latest

J:350269 Kim JY, et al., ARHGEF5 binds Drebrin and affects alpha-tubulin acetylation to direct neuronal morphogenesis and migration during mouse brain development. Front Mol Neurosci. 2024;17:1421932

TSS for Arhgef5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr56053	Chr6:43242550-43242615 (+)	5 bp
Tssr56054	Chr6:43242618-43242646 (+)	54 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24