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Elovl2 Gene Detail
Summary
  • Symbol
    Elovl2
  • Name
    ELOVL fatty acid elongase 2
  • Synonyms
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2, Ssc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858960
    NCBI Gene: 54326
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:41335858-41373879 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 20.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858960
 protein coding gene Chr13:41335857-41373881 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020486
 protein coding gene Chr13:39666379-39705257 (-)
A/J MGP_AJ_G0020440
 protein coding gene Chr13:38344517-38382220 (-)
AKR/J MGP_AKRJ_G0020418
 protein coding gene Chr13:39388133-39425823 (-)
BALB/cJ MGP_BALBcJ_G0020436
 protein coding gene Chr13:38527749-38565534 (-)
C3H/HeJ MGP_C3HHeJ_G0020235
 protein coding gene Chr13:39265183-39302937 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020869
 protein coding gene Chr13:40922848-40960655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018456
 protein coding gene Chr13:36475694-36512737 (-)
CAST/EiJ MGP_CASTEiJ_G0019750
 protein coding gene Chr13:39048968-39085763 (-)
CBA/J MGP_CBAJ_G0020196
 protein coding gene Chr13:42677296-42721677 (-)
DBA/2J MGP_DBA2J_G0020318
 protein coding gene Chr13:37912701-37952726 (-)
FVB/NJ MGP_FVBNJ_G0020297
 protein coding gene Chr13:37408808-37446658 (-)
LP/J MGP_LPJ_G0020393
 protein coding gene Chr13:39910347-39948395 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020326
 protein coding gene Chr13:42640748-42678512 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020912
 protein coding gene Chr13:39034537-39072279 (-)
PWK/PhJ MGP_PWKPhJ_G0019505
 protein coding gene Chr13:37988260-38026715 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019335
 protein coding gene Chr13:37645059-37684484 (-)
WSB/EiJ MGP_WSBEiJ_G0019812
 protein coding gene Chr13:39337796-39377599 (-)



Homology
more
  • Human Ortholog
    ELOVL2, ELOVL fatty acid elongase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ELOVL2, ELOVL fatty acid elongase 2
  • Synonyms
    SSC2
  • Links
    NCBI Gene ID: 54898
    neXtProt AC: NX_Q9NXB9
    UniProt: Q9NXB9

  • Chr Location
    6p24.2; chr6:10980759-11044305 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a knock-out allele exhibit reduced male fertility. Mice homozygous for a KO allele exhibit male infertility associated with arrested spermatogenesis. Homozygous p.C234W mutation leads to accelerated age-related retinal degradation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    125
  • cDNA Data
    45
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54326 NCBI Gene Model | MGI Sequence Detail 38022 C57BL/6J ±  kb
    transcript NM_001311121 RefSeq | MGI Sequence Detail 3914 C57BL/6  
    polypeptide Q9JLJ4 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      cDNA 45
      Primer pair 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2145206
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:346053 Zhang J, et al., Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2. Nat Commun. 2024 Mar 14;15(1):2315
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory