Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | Notes | References

Symbol:	Ift88tm1Rpw
Name:	intraflagellar transport 88; targeted mutation 1, Richard P Woychik
MGI ID:	MGI:1859153
Synonyms:	Ift88delta2-3betagal, Ift99null, Tg737delta2-3betaGal
Gene:	Ift88  Location: Chr14:57661519-57755393 bp, + strand  Genetic Position: Chr14, 30.1 cM
Alliance:	Ift88tm1Rpw page

Germline Transmission:	Earliest citation of germline transmission: J:62025
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A genomic fragment containing exons 2 and part of 3 was replaced with a lacZ gene with a splice acceptor site and neomycin selection cassette. RT-PCR analysis demonstrated that the mutation eliminated expression of the wild-type transcript, and whole-mount embryo staining studies revealed that beta-galactosidase is expressed from this allele. (J:62025)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	68 assay results
In Structures Affected by this Mutation:	16 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ift88 Mutation:	48 strains or lines available

Original:	J:62025 Murcia NS, et al., The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development. 2000 Jun;127(11):2347-55
All:	21 reference(s)