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Prss16 Gene Detail
Summary
  • Symbol
    Prss16
  • Name
    serine protease 16 (thymus)
  • Synonyms
    TSSP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859181
    NCBI Gene: 54373
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:22186346-22193911 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 8.12 cM, cytoband A3-A5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    313 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859181
 protein coding gene Chr13:22186343-22193912 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020306
 protein coding gene Chr13:19321714-19329283 (-)
A/J MGP_AJ_G0020264
 protein coding gene Chr13:18876620-18884189 (-)
AKR/J MGP_AKRJ_G0020236
 protein coding gene Chr13:19205889-19213455 (-)
BALB/cJ MGP_BALBcJ_G0020252
 protein coding gene Chr13:18924191-18931760 (-)
C3H/HeJ MGP_C3HHeJ_G0020060
 protein coding gene Chr13:19298568-19306137 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020691
 protein coding gene Chr13:20002614-20010180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018296
 protein coding gene Chr13:17166738-17173755 (-)
CAST/EiJ MGP_CASTEiJ_G0019583
 protein coding gene Chr13:19095290-19102884 (-)
CBA/J MGP_CBAJ_G0020014
 protein coding gene Chr13:20657644-20665213 (-)
DBA/2J MGP_DBA2J_G0020139
 protein coding gene Chr13:18515754-18523323 (-)
FVB/NJ MGP_FVBNJ_G0020124
 protein coding gene Chr13:18169660-18177229 (-)
LP/J MGP_LPJ_G0020209
 protein coding gene Chr13:19550761-19558343 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020154
 protein coding gene Chr13:21058844-21066413 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020723
 protein coding gene Chr13:19006162-19013728 (-)
PWK/PhJ MGP_PWKPhJ_G0019339
 protein coding gene Chr13:18536461-18544040 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019151
 protein coding gene Chr13:17993317-18000715 (-)
WSB/EiJ MGP_WSBEiJ_G0019644
 protein coding gene Chr13:19124840-19132406 (-)



Homology
more
  • Human Ortholog
    PRSS16, serine protease 16
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRSS16, serine protease 16
  • Synonyms
    TSSP
  • Links
    NCBI Gene ID: 10279
    neXtProt AC: NX_Q9NQE7
    UniProt: Q9NQE7

  • Chr Location
    6p22.1; chr6:27247701-27256624 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable with no gross abnormalities and normal T cell development and activation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    4
  • cDNA Data
    17
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54373 NCBI Gene Model | MGI Sequence Detail 7566 C57BL/6J ±  kb
    transcript NM_019429 RefSeq | MGI Sequence Detail 2152 C57BL/6  
    polypeptide Q9QXE5 UniProt | EBI | MGI Sequence Detail 509 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 18

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145239
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 23
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory