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Irf7 Gene Detail
Summary
  • Symbol
    Irf7
  • Name
    interferon regulatory factor 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859212
    NCBI Gene: 54123
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140843096-140846412 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.57 cM, cytoband F5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859212
 protein coding gene Chr7:140842619-140846412 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033219
 protein coding gene Chr7:146442872-146446647 (-)
A/J MGP_AJ_G0033201
 protein coding gene Chr7:142254328-142258103 (-)
AKR/J MGP_AKRJ_G0033133
 protein coding gene Chr7:146183052-146186827 (-)
BALB/cJ MGP_BALBcJ_G0033202
 protein coding gene Chr7:141998290-142002065 (-)
C3H/HeJ MGP_C3HHeJ_G0032916
 protein coding gene Chr7:145941694-145945469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033713
 protein coding gene Chr7:151794393-151798168 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030686
 protein coding gene Chr7:143463909-143467695 (-)
CAST/EiJ MGP_CASTEiJ_G0032246
 protein coding gene Chr7:138241020-138244776 (-)
CBA/J MGP_CBAJ_G0032888
 protein coding gene Chr7:156925228-156929003 (-)
DBA/2J MGP_DBA2J_G0033040
 protein coding gene Chr7:140203069-140206844 (-)
FVB/NJ MGP_FVBNJ_G0032993
 protein coding gene Chr7:140115324-140119099 (-)
LP/J MGP_LPJ_G0033135
 protein coding gene Chr7:147940990-147944765 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033026
 protein coding gene Chr7:157587350-157591125 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033733
 protein coding gene Chr7:145157121-145160896 (-)
PWK/PhJ MGP_PWKPhJ_G0031950
 protein coding gene Chr7:133481172-133484963 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031797
 protein coding gene Chr7:131980014-131983809 (-)
WSB/EiJ MGP_WSBEiJ_G0032357
 protein coding gene Chr7:146101663-146105438 (-)



Homology
more
  • Human Ortholog
    IRF7, interferon regulatory factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF7, interferon regulatory factor 7
  • Synonyms
    IMD39, IRF-7, IRF7A, IRF7B, IRF7C, IRF-7H, IRF7H
  • Links
    NCBI Gene ID: 3665
    neXtProt AC: NX_Q92985
    UniProt: Q92985

  • Chr Location
    11p15.5; chr11:612553-615983 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IRF7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    185 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are more vulnerable to viral infection and exhibit decreased serum interferon levels in response to viral infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    128
  • cDNA Data
    92
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54123 NCBI Gene Model | MGI Sequence Detail 3317 C57BL/6J ±  kb
    transcript NM_016850 RefSeq | MGI Sequence Detail 1876 C57BL/6  
    polypeptide P70434 UniProt | EBI | MGI Sequence Detail 457 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 2
      cDNA 94
      Primer pair 4
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 272
      Developmental Gene Expression 17
      Gene Ontology 15
      Phenotypes 185
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:354283 Wang C, et al., Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production. Commun Biol. 2024 Sep 17;7(1):1162
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory