Uncxtm1Akis
Targeted Allele Detail
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| Symbol: |
Uncxtm1Akis |
| Name: |
UNC homeobox; targeted mutation 1, Andreas Kispert |
| MGI ID: |
MGI:1859373 |
| Synonyms: |
Uncx4.1del |
| Gene: |
Uncx Location: Chr5:139529620-139533934 bp, + strand Genetic Position: Chr5, 78.75 cM
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| Alliance: |
Uncxtm1Akis page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:62022
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| Parent Cell Line: |
E14 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Intragenic deletion
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Mutation details: A deletion of the entire transcription unit of the Uncx4.1 gene was generated by introducing a loxP site 2-kb upstream of the transcription start site and a loxP-flanked neomycin cassette 5-kb to the second exon. Following homologous recombination in ES cells, cre recombinase was transiently expressed in order to excise loxP flanked sequences. ES cell lines carrying the deleted allele were used to generate founder mice.
(J:62022)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Uncx Mutation: |
28 strains or lines available
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| Original: |
J:62022 Leitges M, et al., The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. Development. 2000 Jun;127(11):2259-67 |
| All: |
3 reference(s) |
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Analysis Tools
