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Dll4 Gene Detail
Summary
  • Symbol
    Dll4
  • Name
    delta like canonical Notch ligand 4
  • Synonyms
    Delta4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859388
    NCBI Gene: 54485
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119156286-119166145 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    180 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859388
 protein coding gene Chr2:119156265-119166443 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026341
 protein coding gene Chr2:122075529-122087550 (+)
A/J MGP_AJ_G0026302
 protein coding gene Chr2:117101591-117111699 (+)
AKR/J MGP_AKRJ_G0026281
 protein coding gene Chr2:120390590-120400877 (+)
BALB/cJ MGP_BALBcJ_G0026315
 protein coding gene Chr2:117366989-117377129 (+)
C3H/HeJ MGP_C3HHeJ_G0026061
 protein coding gene Chr2:120849187-120859368 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026762
 protein coding gene Chr2:126095206-126106415 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024142
 protein coding gene Chr2:112159560-112169411 (+)
CAST/EiJ MGP_CASTEiJ_G0025523
 protein coding gene Chr2:121160536-121171866 (+)
CBA/J MGP_CBAJ_G0026037
 protein coding gene Chr2:130521451-130534285 (+)
DBA/2J MGP_DBA2J_G0026176
 protein coding gene Chr2:116526887-116537330 (+)
FVB/NJ MGP_FVBNJ_G0026138
 protein coding gene Chr2:115348106-115358904 (+)
LP/J MGP_LPJ_G0026277
 protein coding gene Chr2:122392152-122402140 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026157
 protein coding gene Chr2:134870343-134883065 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026817
 protein coding gene Chr2:120505489-120515757 (+)
PWK/PhJ MGP_PWKPhJ_G0025259
 protein coding gene Chr2:116089948-116100319 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025058
 protein coding gene Chr2:119694698-119705378 (+)
WSB/EiJ MGP_WSBEiJ_G0025592
 protein coding gene Chr2:121344718-121356015 (+)



Homology
more
  • Human Ortholog
    DLL4, delta like canonical Notch ligand 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLL4, delta like canonical Notch ligand 4
  • Synonyms
    AOS6, delta4, hdelta2
  • Links
    NCBI Gene ID: 54567
    neXtProt AC: NX_Q9NR61
    UniProt: Q9NR61

  • Chr Location
    15q15.1; chr15:40929340-40939073 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dll4 mouse models; 2 with human DLL4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    60 phenotypes from 8 alleles in 11 genetic backgrounds
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality, absent vascular remodeling, small hearts, and embryonic growth retardation. Heterozygous null mice display background dependent partial or complete embryonic lethality, impaired vascular remodeling, and embryonic growth retardation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    978
  • Tissues
    184
  • cDNA Data
    41
  • Literature Summary
    190
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54485 NCBI Gene Model | MGI Sequence Detail 9860 C57BL/6J ±  kb
    transcript NM_019454 RefSeq | MGI Sequence Detail 3413 C57BL/6  
    polypeptide Q9JI71 UniProt | EBI | MGI Sequence Detail 686 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      Genomic 1
      cDNA 42
      Primer pair 9
      Other 6

      Microarray probesets 4
    References
    more
    • Summaries
      All 323
      Developmental Gene Expression 190
      Diseases 1
      Gene Ontology 19
      Phenotypes 85
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355651 El Azhar Y, et al., Unravelling differential Hes1 dynamics during axis elongation of mouse embryos through single-cell tracking. Development. 2024 Sep 15;151(18):dev202936
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory