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Syt11 Gene Detail
Summary
  • Symbol
    Syt11
  • Name
    synaptotagmin XI
  • Synonyms
    6530420C11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859547
    NCBI Gene: 229521
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88652006-88682466 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 38.96 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    651 from dbSNP Build 142
  • Strain Annotations
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859547
 protein coding gene Chr3:88652006-88682471 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0027372
 protein coding gene Chr3:85917182-86075105 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0025179
 protein coding gene Chr3:81523135-81554123 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0027203
 protein coding gene Chr3:83670892-83698958 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027886
 protein coding gene Chr3:87785052-87897195 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0026122
 protein coding gene Chr3:86961948-87011472 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SYT11, synaptotagmin 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYT11, synaptotagmin 11
  • Synonyms
    SYT12, sytXI
  • Links
    NCBI Gene ID: 23208
    neXtProt AC: NX_Q9BT88
    UniProt: Q9BT88

  • Chr Location
    1q22; chr1:155859567-155885199 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotype references
Homozygous mutation of this gene results in no obvious abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    104
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    145
  • cDNA Data
    14
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 229521 NCBI Gene Model | MGI Sequence Detail 30461 C57BL/6J ±  kb
transcript NM_018804 RefSeq | MGI Sequence Detail 4585 ZRU/MplStud  
polypeptide Q9R0N3 UniProt | EBI | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:1923498, MGI:2139826
References
more
  • Summaries
    All 56
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 16
    Phenotypes 15
  • Earliest
    J:62060 Fukuda M, et al., Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7
  • Latest
    J:348013 Zhang F, et al., Synaptotagmin-11 regulates immune functions of microglia in vivo. J Neurochem. 2023 Dec;167(5):680-695
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory