Fgf10<tm1Ska> Targeted Allele Detail MGI Mouse (MGI:1859647)

Fgf10^tm1Ska
Targeted Allele Detail

Summary

Symbol:	Fgf10^tm1Ska
Name:	fibroblast growth factor 10; targeted mutation 1, Shigeaki Kato
MGI ID:	MGI:1859647
Synonyms:	fgf10-
Gene:	Fgf10 Location: Chr13:118851199-118928651 bp, + strand Genetic Position: Chr13, 67.14 cM, cytoband A3-A4
Alliance:	Fgf10^tm1Ska page

Submandibular gland abnormalities in Fgf10^tm1Ska/Fgf10^tm1Ska and Fgfr2^tm1.1Dsn/Fgfr2^tm1.1Dsn mice at E12.5

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:51966
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced 1.1 kb of sequence that contains the exon encoding the ATG translation initiation site and the amino terminal 110 amino acids of the encoded protein. (J:51966)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	144 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	53 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Fgf10 Mutation:	33 strains or lines available

References

Original:	J:51966 Sekine K, et al., Fgf10 is essential for limb and lung formation. Nat Genet. 1999 Jan;21(1):138-41
All:	57 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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