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Slc23a2 Gene Detail
Summary
  • Symbol
    Slc23a2
  • Name
    solute carrier family 23 (nucleobase transporters), member 2
  • Synonyms
    mKIAA0238, Slc23a1, SVCT2, YSPL3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859682
    NCBI Gene: 54338
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:131894416-131987028 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 64.15 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859682
 protein coding gene Chr2:131894416-131987287 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026538
 protein coding gene Chr2:135612472-135677518 (-)
A/J MGP_AJ_G0026502
 protein coding gene Chr2:130089161-130181214 (-)
AKR/J MGP_AKRJ_G0026477
 protein coding gene Chr2:133835349-133936809 (-)
BALB/cJ MGP_BALBcJ_G0026514
 protein coding gene Chr2:130481090-130573997 (-)
C3H/HeJ MGP_C3HHeJ_G0026257
 protein coding gene Chr2:134294835-134391396 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026959
 protein coding gene Chr2:139735394-139831655 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024336
 protein coding gene Chr2:124819269-124909813 (-)
CAST/EiJ MGP_CASTEiJ_G0025718
 protein coding gene Chr2:134606068-134703937 (-)
CBA/J MGP_CBAJ_G0026237
 protein coding gene Chr2:144985386-145088264 (-)
DBA/2J MGP_DBA2J_G0026371
 protein coding gene Chr2:129488239-129581665 (-)
FVB/NJ MGP_FVBNJ_G0026335
 protein coding gene Chr2:128115248-128211326 (-)
LP/J MGP_LPJ_G0026476
 protein coding gene Chr2:135817471-135912903 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026355
 protein coding gene Chr2:148770995-148867014 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027014
 protein coding gene Chr2:133811215-133912612 (-)
PWK/PhJ MGP_PWKPhJ_G0025454
 protein coding gene Chr2:129072190-129168087 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025256
 protein coding gene Chr2:132963604-133060486 (-)
WSB/EiJ MGP_WSBEiJ_G0025792
 protein coding gene Chr2:134739860-134835531 (-)



Homology
more
  • Human Ortholog
    SLC23A2, solute carrier family 23 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC23A2, solute carrier family 23 member 2
  • Synonyms
    NBTL1, SLC23A1, SVCT2, YSPL2
  • Links
    NCBI Gene ID: 9962
    neXtProt AC: NX_Q9UGH3
    UniProt: Q9UGH3

  • Chr Location
    20p13; chr20:4852356-5010313 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die within minutes of birth from respiratory distress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    90
  • cDNA Data
    7
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027340 Ensembl Gene Model | MGI Sequence Detail 92613 C57BL/6J ±  kb
    transcript ENSMUST00000028815 Ensembl | MGI Sequence Detail 6364 Not Applicable  
    polypeptide ENSMUSP00000028815 Ensembl | MGI Sequence Detail 648 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139069
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:338914 Cao B, et al., Construction of a Brain-specific SLC23A2 Gene Knockout Mice Model. Neuroscience. 2023 Aug 1;524:137-148
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory