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Rgs14 Gene Detail
Summary
  • Symbol
    Rgs14
  • Name
    regulator of G-protein signaling 14
  • Synonyms
    Rap1/rap2 interacting protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859709
    NCBI Gene: 51791
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55517545-55532500 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 29.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    378 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859709
 protein coding gene Chr13:55517269-55532504 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020593
 protein coding gene Chr13:54846028-54861413 (+)
A/J MGP_AJ_G0020547
 protein coding gene Chr13:52820015-52834992 (+)
AKR/J MGP_AKRJ_G0020525
 protein coding gene Chr13:54373566-54388477 (+)
BALB/cJ MGP_BALBcJ_G0020543
 protein coding gene Chr13:53048961-53063950 (+)
C3H/HeJ MGP_C3HHeJ_G0020342
 protein coding gene Chr13:54191798-54207159 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020977
 protein coding gene Chr13:56498300-56513235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018559
 protein coding gene Chr13:50768997-50784310 (+)
CAST/EiJ MGP_CASTEiJ_G0019856
 protein coding gene Chr13:54292005-54307042 (+)
CBA/J MGP_CBAJ_G0020302
 protein coding gene Chr13:58664779-58679982 (+)
DBA/2J MGP_DBA2J_G0020425
 protein coding gene Chr13:52371520-52386866 (+)
FVB/NJ MGP_FVBNJ_G0020404
 protein coding gene Chr13:51840503-51855404 (+)
LP/J MGP_LPJ_G0020501
 protein coding gene Chr13:55104540-55119542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020433
 protein coding gene Chr13:58136803-58151733 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021020
 protein coding gene Chr13:53965235-53980350 (+)
PWK/PhJ MGP_PWKPhJ_G0019612
 protein coding gene Chr13:52397614-52416390 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019439
 protein coding gene Chr13:52884021-52900622 (+)
WSB/EiJ MGP_WSBEiJ_G0019918
 protein coding gene Chr13:54322085-54337082 (+)



Homology
more
  • Human Ortholog
    RGS14, regulator of G protein signaling 14
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS14, regulator of G protein signaling 14
  • Links
    NCBI Gene ID: 10636
    neXtProt AC: NX_O43566
    UniProt: O43566

  • Chr Location
    5q35.3; chr5:177357924-177372596 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RGS14 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for one knockout allele results in failure to complete the first zygotic cell division. Another homozygous KO affects long-term potentiation in hippocampal neurons which leads to enhanced spatial learning and long-term memory. A third homozygous KO results in no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    746
  • Tissues
    24
  • cDNA Data
    11
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052087 Ensembl Gene Model | MGI Sequence Detail 14956 C57BL/6J ±  kb
transcript ENSMUST00000063771 Ensembl | MGI Sequence Detail 2356 Not Applicable  
polypeptide ENSMUSP00000068731 Ensembl | MGI Sequence Detail 547 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 15
    Phenotypes 21
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:350529 Samadi M, et al., Mechanisms of mGluR-dependent plasticity in hippocampal area CA2. Hippocampus. 2023 Jun;33(6):730-744
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory