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Fezf2 Gene Detail
Summary
  • Symbol
    Fezf2
  • Name
    Fez family zinc finger 2
  • Synonyms
    Fez, Fezl, forebrain embryonic zinc finger, Zfp312
  • Feature Type
    protein coding gene
  • IDs
    MGI:1859823
    NCBI Gene: 54713
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:10121574-10127669 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 6.36 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    118 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1859823
 protein coding gene Chr14:10121561-10130771 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020999
 protein coding gene Chr14:4753142-4758760 (-)
A/J MGP_AJ_G0020947
 protein coding gene Chr14:4663758-4667731 (-)
AKR/J MGP_AKRJ_G0020924
 protein coding gene Chr14:4742895-4746864 (-)
BALB/cJ MGP_BALBcJ_G0020950
 protein coding gene Chr14:4653605-4657752 (-)
C3H/HeJ MGP_C3HHeJ_G0020734
 protein coding gene Chr14:4775098-4779082 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021383
 protein coding gene Chr14:4930340-4937128 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018952
 protein coding gene Chr14:5393473-5397462 (-)
CAST/EiJ MGP_CASTEiJ_G0020256
 protein coding gene Chr14:4765291-4769279 (-)
CBA/J MGP_CBAJ_G0020700
 protein coding gene Chr14:5065707-5069677 (-)
DBA/2J MGP_DBA2J_G0020823
 protein coding gene Chr14:4605378-4609362 (-)
FVB/NJ MGP_FVBNJ_G0020805
 protein coding gene Chr14:4570602-4575005 (-)
LP/J MGP_LPJ_G0020899
 protein coding gene Chr14:4719537-4724358 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020831
 protein coding gene Chr14:5165976-5169976 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021416
 protein coding gene Chr14:4721369-4725995 (-)
PWK/PhJ MGP_PWKPhJ_G0020008
 protein coding gene Chr14:4612794-4617147 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019828
 protein coding gene Chr14:4775945-4779944 (-)
WSB/EiJ MGP_WSBEiJ_G0020314
 protein coding gene Chr14:4745151-4749839 (-)



Homology
more
  • Human Ortholog
    FEZF2, FEZ family zinc finger 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FEZF2, FEZ family zinc finger 2
  • Synonyms
    FEZ, FEZL, FKSG36, TOF, ZFP312, ZNF312
  • Links
    NCBI Gene ID: 55079
    neXtProt AC: NX_Q8TBJ5
    UniProt: Q8TBJ5

  • Chr Location
    3p14.2; chr3:62369681-62374324 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 5 alleles in 7 genetic backgrounds
    15 phenotypes from multigenic genotypes
    1 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show hyperactivity, altered feeding behavior leading to delayed growth and premature death, and impaired formation of subplate neurons and thalamocortical projections. Homozygotes for another allele lack a corpus callosum and show severe subcortical projection defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1070
  • Tissues
    192
  • cDNA Data
    22
  • Literature Summary
    89
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021743 Ensembl Gene Model | MGI Sequence Detail 6096 C57BL/6J ±  kb
    transcript ENSMUST00000022262 Ensembl | MGI Sequence Detail 2188 Not Applicable  
    polypeptide ENSMUSP00000022262 Ensembl | MGI Sequence Detail 455 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 23
      Primer pair 5
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145654, MGI:2145702
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 89
      Gene Ontology 13
      Phenotypes 55
    • Earliest
      J:62051 Matsuo-Takasaki M, et al., Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mech Dev. 2000 May;93(1-2):201-4
    • Latest
      J:354227 Barao S, et al., Conserved transcriptional regulation by BRN1 and BRN2 in neocortical progenitors drives mammalian neural specification and neocortical expansion. Nat Commun. 2024 Sep 14;15(1):8043
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory