Tnfrsf4tm1Nik
Targeted Allele Detail
|
|
| Symbol: |
Tnfrsf4tm1Nik |
| Name: |
tumor necrosis factor receptor superfamily, member 4; targeted mutation 1, Nigel Killeen |
| MGI ID: |
MGI:1859871 |
| Synonyms: |
CD134-, OX40-, OX40 KO |
| Gene: |
Tnfrsf4 Location: Chr4:156098300-156101069 bp, + strand Genetic Position: Chr4, 87.68 cM
|
| Alliance: |
Tnfrsf4tm1Nik page
|
|
Lung inflammatory infiltrates, goblet cell hyperplasia, and mucus production are reduced in Tnfrsf4tm1Nik/Tnfrsf4tm1Nik mice
Show the 1 phenotype image(s) involving this allele.
|
|
|
| Germline Transmission: |
Earliest citation of germline transmission:
J:58979
|
| Parent Cell Line: |
RF8 (ES Cell)
|
| Strain of Origin: |
129S4/SvJae
|
|
| Allele Type: |
|
Targeted (Null/knockout) |
| Mutations: |
|
Insertion, Intragenic deletion
|
| |
|
Mutation details: A neomycin cassette was used to replace four exons, which code for the first 143 amino acids of the protein. Activated T cells from homozygous mutant animals lacked expression of Tnfrsf4 as detected by flow cytometry with the OX86 mAb as well as a soluable ligand fusion protein.
(J:58979)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
|
| Original: |
J:58979 Pippig SD, et al., Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). J Immunol. 1999 Dec 15;163(12):6520-9 |
| All: |
46 reference(s) |
|
Analysis Tools
