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Tnp1tm1Mlm
Targeted Allele Detail
Summary
Symbol: Tnp1tm1Mlm
Name: transition protein 1; targeted mutation 1, Marvin L Meistrich
MGI ID: MGI:1859961
Synonyms: Tnp1-, Tnp1-null
Gene: Tnp1  Location: Chr1:73054233-73055058 bp, - strand  Genetic Position: Chr1, 36.94 cM
Alliance: Tnp1tm1Mlm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61941
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: The entire gene was replaced with a neomycin cassette, which was inserted in an antisense orientation. Tnp1 protein was not detectable in extracts of testicular homogenates from homozygous mutant mice. (J:61941)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnp1 Mutation:  4 strains or lines available
References
Original:  J:61941 Yu YE, et al., Abnormal spermatogenesis and reduced fertility in transition nuclear protein 1-deficient mice. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4683-8
All:  6 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory