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Olfm1 Gene Detail
Summary
  • Symbol
    Olfm1
  • Name
    olfactomedin 1
  • Synonyms
    Noelin 1, Noelin 2, Pancortin 1-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860437
    NCBI Gene: 56177
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:28083105-28120748 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.38 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    948 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860437
 protein coding gene Chr2:28083004-28120748 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025519
 protein coding gene Chr2:26213391-26254872 (+)
A/J MGP_AJ_G0025496
 protein coding gene Chr2:25244881-25282415 (+)
AKR/J MGP_AKRJ_G0025466
 protein coding gene Chr2:26082598-26120147 (+)
BALB/cJ MGP_BALBcJ_G0025492
 protein coding gene Chr2:25361269-25400147 (+)
C3H/HeJ MGP_C3HHeJ_G0025253
 protein coding gene Chr2:25982401-26020604 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025936
 protein coding gene Chr2:27115899-27158288 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023347
 protein coding gene Chr2:24051207-24088921 (+)
CAST/EiJ MGP_CASTEiJ_G0024716
 protein coding gene Chr2:25894391-25933429 (+)
CBA/J MGP_CBAJ_G0025231
 protein coding gene Chr2:28035053-28075172 (+)
DBA/2J MGP_DBA2J_G0025364
 protein coding gene Chr2:25052476-25090021 (+)
FVB/NJ MGP_FVBNJ_G0025326
 protein coding gene Chr2:24827810-24866558 (+)
LP/J MGP_LPJ_G0025450
 protein coding gene Chr2:26174167-26213841 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025357
 protein coding gene Chr2:28037811-28076649 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025995
 protein coding gene Chr2:25978449-26018133 (+)
PWK/PhJ MGP_PWKPhJ_G0024464
 protein coding gene Chr2:24852161-24889964 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024264
 protein coding gene Chr2:26142880-26184213 (+)
WSB/EiJ MGP_WSBEiJ_G0024785
 protein coding gene Chr2:26119492-26156826 (+)



Homology
more
  • Human Ortholog
    OLFM1, olfactomedin 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OLFM1, olfactomedin 1
  • Synonyms
    AMY, NOE1, NOELIN1, OlfA
  • Links
    NCBI Gene ID: 10439
    neXtProt AC: NX_Q99784
    UniProt: Q99784

  • Chr Location
    9q34.3; chr9:135075422-135121184 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display reduced cerebral infarction size in males, decreased body weight and defects in embryo implantation, mating activity and ovulation in females, and reduced female fertility most likely as a secondary effect of impaired olfaction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1170
  • Tissues
    128
  • cDNA Data
    13
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56177 NCBI Gene Model | MGI Sequence Detail 37644 C57BL/6J ±  kb
    transcript NM_019498 RefSeq | MGI Sequence Detail 2727 Not Specified  
    polypeptide O88998 UniProt | EBI | MGI Sequence Detail 485 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 13
      Primer pair 4
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2139410
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 9
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:346373 Liu B, et al., NPC1 is required for postnatal islet beta cell differentiation by maintaining mitochondria turnover. Theranostics. 2024;14(5):2058-2074
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory