Th<tm1Rpa> Targeted Allele Detail MGI Mouse (MGI:1860450)

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Th^tm1Rpa
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Th^tm1Rpa
Name:	tyrosine hydroxylase; targeted mutation 1, Richard D Palmiter
MGI ID:	MGI:1860450
Synonyms:	DA-, pTH4, TH^-
Gene:	Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
Alliance:	Th^tm1Rpa page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:24347
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		A neomycin selection cassette replaced the proximal promoter and exons 1 and 2. (J:24347)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Th Mutation:	58 strains or lines available

References

Original:	J:24347 Zhou QY, et al., Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature. 1995 Apr 13;374(6523):640-3
All:	14 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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