Thtm1Rpa
Targeted Allele Detail
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| Symbol: |
Thtm1Rpa |
| Name: |
tyrosine hydroxylase; targeted mutation 1, Richard D Palmiter |
| MGI ID: |
MGI:1860450 |
| Synonyms: |
DA-, pTH4, TH- |
| Gene: |
Th Location: Chr7:142446516-142453732 bp, - strand Genetic Position: Chr7, 88.06 cM
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| Alliance: |
Thtm1Rpa page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:24347
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| Parent Cell Line: |
AB1 (ES Cell)
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| Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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| |
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A neomycin selection cassette replaced the proximal promoter and exons 1 and 2. (J:24347)
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| Inheritance: |
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Recessive |
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| Key: |
| hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
| cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/
Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
|---|
Loading... | | | involves: 129S7/SvEvBrd * C57BL/6 | | | | involves: 129S7/SvEvBrd | | | | involves: 129S7/SvEvBrd * C57BL/6J | |
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| Phenotypes: |
| Affected Systems |
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behavior/neurological
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√
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√
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√
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impaired behavioral response to addictive substance
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√
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adipsia
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√
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aphagia
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√
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decreased food intake
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√
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decreased compensatory feeding amount
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√
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poor grooming
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√
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hyporesponsive to tactile stimuli
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√
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abnormal motor coordination/balance
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√
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impaired coordination
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√
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weakness
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√
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hunched posture
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√
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√
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akinesia
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√
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abnormal gait
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√
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decreased locomotor activity
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√
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√
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hyperactivity
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√
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decreased stereotypic behavior
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√
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increased stereotypic behavior
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√
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catalepsy
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√
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cardiovascular system
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√
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blood vessel congestion
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√
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liver vascular congestion
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√
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fetal cardiomyocyte disarray
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√
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fetal cardiomyocyte vacuoles
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√
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abnormal heart atrium morphology
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√
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dilated heart atrium
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√
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decreased heart rate
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√
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growth/size/body
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√
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√
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decreased body size
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√
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√
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decreased body weight
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√
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√
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weight loss
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√
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homeostasis/metabolism
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√
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decreased dopamine level
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√
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liver/biliary system
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√
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liver vascular congestion
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√
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mortality/aging
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√
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√
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√
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premature death
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√
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√
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postnatal lethality, complete penetrance
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√
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lethality throughout fetal growth and development, incomplete penetrance
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√
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embryonic lethality during organogenesis, incomplete penetrance
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√
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nervous system
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√
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decreased brain size
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√
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abnormal nervous system physiology
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√
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:24347 Zhou QY, et al., Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development. Nature. 1995 Apr 13;374(6523):640-3 |
| All: |
14 reference(s) |
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Analysis Tools