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Arhgef7 Gene Detail
Summary
  • Symbol
    Arhgef7
  • Name
    Rho guanine nucleotide exchange factor
  • Synonyms
    betaPix, betaPix-b, betaPix-c, Cool, cool-1, p85SPR, Pak interacting exchange factor, PIX
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860493
    NCBI Gene: 54126
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:11778053-11885219 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 5.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2629 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860493
 protein coding gene Chr8:11777721-11885219 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033359
 protein coding gene Chr8:8975675-9089307 (+)
A/J MGP_AJ_G0033339
 protein coding gene Chr8:8657051-8770334 (+)
AKR/J MGP_AKRJ_G0033270
 protein coding gene Chr8:8911920-9021760 (+)
BALB/cJ MGP_BALBcJ_G0033340
 protein coding gene Chr8:8795097-8902812 (+)
C3H/HeJ MGP_C3HHeJ_G0033053
 protein coding gene Chr8:9081696-9194757 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033852
 protein coding gene Chr8:9326220-9439315 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030821
 protein coding gene Chr8:8178899-8298793 (+)
CAST/EiJ MGP_CASTEiJ_G0032375
 protein coding gene Chr8:8830560-8937993 (+)
CBA/J MGP_CBAJ_G0033026
 protein coding gene Chr8:9726758-9840681 (+)
DBA/2J MGP_DBA2J_G0033179
 protein coding gene Chr8:8632405-8739504 (+)
FVB/NJ MGP_FVBNJ_G0033128
 protein coding gene Chr8:8599227-8712703 (+)
LP/J MGP_LPJ_G0033273
 protein coding gene Chr8:8896813-9010858 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033162
 protein coding gene Chr8:10017851-10129864 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033869
 protein coding gene Chr8:8926729-9040991 (+)
PWK/PhJ MGP_PWKPhJ_G0032088
 protein coding gene Chr8:8637776-8745129 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031930
 protein coding gene Chr8:8835373-8945406 (+)
WSB/EiJ MGP_WSBEiJ_G0032491
 protein coding gene Chr8:8967162-9081346 (+)



Homology
more
  • Human Ortholog
    ARHGEF7, Rho guanine nucleotide exchange factor 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGEF7, Rho guanine nucleotide exchange factor 7
  • Synonyms
    BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB
  • Links
    NCBI Gene ID: 8874
    neXtProt AC: NX_Q14155
    UniProt: Q14155

  • Chr Location
    13q34; chr13:111114559-111305737 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit placental defects and complete lethality throughout fetal growth and development. Mice homozygous for a different null allele exhibit embryonic death around E8.5, double axis, and impaired anterior visceral endoderm cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    755
  • Tissues
    46
  • cDNA Data
    175
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54126 NCBI Gene Model | MGI Sequence Detail 107167 C57BL/6J ±  kb
    transcript NM_001113517 RefSeq | MGI Sequence Detail 4973 C57BL/6  
    polypeptide Q9ES28 UniProt | EBI | MGI Sequence Detail 862 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 178
      Genomic 1
      cDNA 176
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 10
      Gene Ontology 21
      Phenotypes 21
    • Earliest
      J:63104 Oh WK, et al., Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. Biochem Biophys Res Commun. 1997 Jun 27;235(3):794-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory