Tlr4<lps-del> Spontaneous Allele Detail MGI Mouse (MGI:1860755)

Tlr4^lps-del
Spontaneous Allele Detail

Summary

Symbol:	Tlr4^lps-del
Name:	toll-like receptor 4; defective lipopolysaccharide response, deletion
MGI ID:	MGI:1860755
Synonyms:	Tlr4^-, TLR4-KO, TLR4^lps-
Gene:	Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4^lps-del page

Mutation
origin

Strain of Origin:

C57BL/10ScN

Mutation
description

Allele Type:		Spontaneous (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: This allele has been characterized by lack of mRNA owing to a deletion of the locus. 74723bp of genomic DNA sequence have been removed, encompassing only the Tlr4 gene. (J:51522, J:122203)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	91 strains or lines available

Notes

C57BL/10ScN, C57BL/10ScNJ, and C57BL10/ScCr mice carry this allele.

References

Original:	J:6086 Vogel SN, et al., Characterization of a congenitally LPS-resistant, athymic mouse strain. J Immunol. 1979 Feb;122(2):619-22
All:	356 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24