Tlr4<tm1Aki> Targeted Allele Detail MGI Mouse (MGI:1860885)

Tlr4^tm1Aki
Targeted Allele Detail

Summary

Symbol:	Tlr4^tm1Aki
Name:	toll-like receptor 4; targeted mutation 1, Shizuo Akira
MGI ID:	MGI:1860885
Synonyms:	TLR4-, TLR4 KO, TLR4-KO
Gene:	Tlr4 Location: Chr4:66745788-66765338 bp, + strand Genetic Position: Chr4, 34.66 cM
Alliance:	Tlr4^tm1Aki page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:53519
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: Genomic sequences encoding the transmembrane and cytoplasmic domains (amino acids 86-835) were replaced with a neomycin cassette. Northern blot analysis revealed that no mRNA is produced from this allele in splenocytes derived from homozygous mice. (J:53519, J:91950)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available Cell Lines: 0 lines available
Carrying any Tlr4 Mutation:	91 strains or lines available

References

Original:	J:53519 Hoshino K, et al., Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol. 1999 Apr 1;162(7):3749-52
All:	725 reference(s)

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