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Ltbtm1Flv
Targeted Allele Detail
Summary
Symbol: Ltbtm1Flv
Name: lymphotoxin B; targeted mutation 1, Richard A Flavell
MGI ID: MGI:1860955
Synonyms: LT beta-, LTbeta-
Gene: Ltb  Location: Chr17:35413483-35415281 bp, + strand  Genetic Position: Chr17, 18.59 cM
Alliance: Ltbtm1Flv page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39746
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced a 0.7 kb fragment of the gene, truncating the coding sequence at codon 153. Northern blots of total RNA from splenocytes from homozygous mutant mice showed an absence of mRNA for the targeted gene. (J:39746, J:95222)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ltb Mutation:  19 strains or lines available
References
Original:  J:39746 Koni PA, et al., Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 1997 Apr;6(4):491-500
All:  34 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory