Ltbtm1Kpf
Targeted Allele Detail
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| Symbol: |
Ltbtm1Kpf |
| Name: |
lymphotoxin B; targeted mutation 1, Klaus Pfeffer |
| MGI ID: |
MGI:1860970 |
| Synonyms: |
LTbeta-, LT beta delta |
| Gene: |
Ltb Location: Chr17:35413483-35415281 bp, + strand Genetic Position: Chr17, 18.59 cM
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| Alliance: |
Ltbtm1Kpf page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:42508
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| Parent Cell Line: |
E14.1 (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A neomycin resistance cassette flanked by loxP sites (floxed) replaced exon 3 of the gene. Mice carrying this allele were bred to mice that constitutively expressed cre-recombinase in all cells in early development (Schwenk et al., Nucleic Acids Res, 1995, 23:5080-5081). Resulting mice carrying the desired deletion were intercrossed to yield homozygous mutant mice at the desired locus. Northern blots of thymocytes and Con-A stimulated splenocytes from homozygous mutant mice showed no dectectable mRNA for the targeted gene.
(J:42508)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Ltb Mutation: |
19 strains or lines available
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| Original: |
J:42508 Alimzhanov MB, et al., Abnormal development of secondary lymphoid tissues in lymphotoxin beta-deficient mice. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9302-7 |
| All: |
31 reference(s) |
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Analysis Tools
