Med1<tm1Jkr> Targeted Allele Detail MGI Mouse (MGI:1861123)

Med1^tm1Jkr
Targeted Allele Detail

Summary

Symbol:	Med1^tm1Jkr
Name:	mediator complex subunit 1; targeted mutation 1, Janardan K Reddy
MGI ID:	MGI:1861123
Synonyms:	PBP^-
Gene:	Med1 Location: Chr11:98042980-98084119 bp, - strand Genetic Position: Chr11, 61.75 cM, cytoband D
Alliance:	Med1^tm1Jkr page

Histological and ultrastructural alterations in Med1^tm1Jkr/Med1^tm1Jkr placenta

Show the 5 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:62272
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1^b-m3

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		Mutation details: Exons 12-14 were disrupted with a PGK-neo cassette via homologous recombination resulting in the loss of 2 LXXLL motifs. Northern and Western blot analysis of fibroblasts from homozygous mutant embryos showed absence of gene transcript and protein product. (J:62272)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Med1 Mutation:	83 strains or lines available

References

Original:	J:62272 Zhu Y, et al., Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem. 2000 May 19;275(20):14779-82
All:	2 reference(s)

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