Clec4n MGI Mouse Gene Detail - MGI:1861231 - C-type lectin domain family 4, member n

Symbol

Clec4n
Name

C-type lectin domain family 4, member n
Synonyms

Clecsf10, dectin-2, Nkcl

Feature Type

protein coding gene
IDs

MGI:1861231
NCBI Gene: 56620
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:123206802-123223980 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 58.30 cM, cytoband F3
Mapping Data

6 experiments

SNPs within 2kb

504 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861231	protein coding gene	Chr6:123206802-123223983 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031242	protein coding gene	Chr6:126379160-126396520 (+)
A/J	MGP_AJ_G0031211	protein coding gene	Chr6:121550135-121562518 (+)
AKR/J	MGP_AKRJ_G0031141	protein coding gene	Chr6:124928244-124939568 (+)
BALB/cJ	MGP_BALBcJ_G0031221	protein coding gene	Chr6:121276088-121288629 (+)
C3H/HeJ	MGP_C3HHeJ_G0030940	protein coding gene	Chr6:124891915-124892887 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031680	protein coding gene	Chr6:129706242-129720645 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028836	protein coding gene	Chr6:118124338-118131551 (+)
CAST/EiJ	MGP_CASTEiJ_G0030329	protein coding gene	Chr6:125133952-125149211 (+)
CBA/J	MGP_CBAJ_G0030903	protein coding gene	Chr6:134775389-134797657 (+)
DBA/2J	MGP_DBA2J_G0031059	protein coding gene	Chr6:120503745-120519430 (+)
FVB/NJ	MGP_FVBNJ_G0031011	protein coding gene	Chr6:119437326-119448446 (+)
LP/J	MGP_LPJ_G0031140	protein coding gene	Chr6:126552933-126563015 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031047	protein coding gene	Chr6:138709202-138728137 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031709	protein coding gene	Chr6:124825038-124838643 (+)
PWK/PhJ	MGP_PWKPhJ_G0030043	protein coding gene	Chr6:119324680-119337866 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029871	protein coding gene	Chr6:122949297-122963459 (+)
WSB/EiJ	MGP_WSBEiJ_G0030411	protein coding gene	Chr6:125119781-125133134 (+)

Human Ortholog

CLEC6A, C-type lectin domain containing 6A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLEC6A, C-type lectin domain containing 6A
Synonyms

CLEC4N, CLECSF10, dectin-2, hDECTIN-2
Links

HGNC:14556

NCBI Gene ID: 93978

neXtProt AC: NX_Q6EIG7

UniProt: Q6EIG7
Chr Location

chr12:8455962-8478330 (+) GRCh38

MGI Vertebrate Homology

Clec4n stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CLEC6A
Gene Tree

Clec4n

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Phenotype Summary

27 phenotypes from 2 alleles in 3 genetic backgrounds
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele have defective responses to Candida albicans.

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All GO Annotations

28
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

730
Tissues

16
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

50
RefSeq

6
UniProt

5
CCDS

CCDS20512.1, CCDS51895.1, CCDS51896.1

Ensembl

ENSMUSG00000023349 (Evidence)
NCBI Gene

56620

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023349	Ensembl Gene Model \| MGI Sequence Detail	17179	C57BL/6J	± kb
transcript	ENSMUST00000024118	Ensembl \| MGI Sequence Detail	1229	Not Applicable
polypeptide	ENSMUSP00000024118	Ensembl \| MGI Sequence Detail	209	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000001806 C-type lectin domain family 6 member A

(term hierarchy)
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily
GlyGen

Q9JKF4 1 site

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All nucleic 13

cDNA 10

Primer pair 1

Other 2

Microarray probesets 3

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MGI:1341853

Summaries

All 93

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 48
Earliest

J:55818 Fernandes MJ, et al., Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 1999 Jun 1;59(11):2709-17
Latest

J:344288 Muraosa Y, et al., Fungal chitin-binding glycoprotein induces Dectin-2-mediated allergic airway inflammation synergistically with chitin. PLoS Pathog. 2024 Jan;20(1):e1011878

TSS for Clec4n:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58764	Chr6:123206806-123206822 (+)	12 bp
Tssr58765	Chr6:123206881-123206886 (+)	82 bp
Tssr58766	Chr6:123214055-123214080 (+)	7,266 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24